Evidence map›Paper›PMID 38946966›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Internalizing Psychiatric Symptoms in People with Mosaicism for Trisomy 21.

Ruth C Brown, Allison D'Aguilar, Quinn Hurshman, Rebekah NailorZee, Timothy P York, George Capone, Ananda B Amstadter, Colleen Jackson-Cook

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Ruth C BrownVirginia Commonwealth University, Department of Psychiatry.ORCID 0000-0001-8614-1645
Allison D'AguilarVirginia Commonwealth University, Department of Psychiatry.
Quinn HurshmanVirginia Commonwealth University, Department of Human & Molecular Genetics.
Rebekah NailorZeeVirginia Commonwealth University, Department of Human & Molecular Genetics.
Timothy P YorkVirginia Commonwealth University, Department of Human & Molecular Genetics.
George CaponeJohns Hopkins University, Kennedy Krieger Institute.
Ananda B AmstadterVirginia Commonwealth University, Department of Psychiatry.
Colleen Jackson-CookVirginia Commonwealth University, Department of Pathology.

Funding

Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
Impact of COVID-19 on the Mental Health of People with Down SyndromeK08HD092610 · NICHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI BROWN, RUTH C · 2018 to 2022
$926k
NCATS NIH HHS UL1 TR002649NICHD NIH HHS K08 HD092610
6 · The paper itself

Abstract

People with mosaicism for trisomy 21 have been shown to exhibit the many of same phenotypic traits present in people with non-mosaic Down syndrome, but with varying symptom severity. However, the behavioral phenotype of people with mosaic Down syndrome (mDS) has not been well characterized. This study aimed to examine the prevalence of self-report and caregiver-report symptoms of depression and anxiety among a sample of 62 participants with mDS aged 12 - 46, and assess their association with the percentage of trisomy 21 in blood and/or buccal mucosa cells. The results showed that 53% of the participants reported clinically significant depression symptoms and 76% reported clinically significant anxiety symptoms. No clear associations were observed between the percentage of trisomic cells and total anxiety or depression, but a significant positive association between the proband-reported specific fears subscale and the percentage of trisomic cells in buccal specimens was detected (

Indexed as

AnxietyDepressionMosaic Down syndromeTrisomy 21

Identifiers

PMID38946966
PMCPMC11213060

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.