ArticleAnimal models and experimental medicine2024
Development of an animal model of hypothyroxinemia during pregnancy in Wistar rats.
Article in Animal models and experimental medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Gestational hypothyroxinemia causes an inflammatory environment at maternal-fetal tissues and fetal brain with impaired hippocampal dendritic spine maturation in the offspring.Scientific reports · 2025Article
- Development of an animal model of hypothyroxinemia during pregnancy in Wistar rats.Animal models and experimental medicine · 2024Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundHypothyroxinemia is a subclinical thyroid hormone deficiency in which the mother has inadequate levels of T
methodsThe animals were administered 1 ppm of propylthiouracil (PTU) for 9 weeks. Then, the concentrations of T
resultsThe ELISA test showed that the serum T
conclusionThe animal model of IMH was developed by the administration of 1 ppm of PTU for 9 weeks, and there were autistic-like behavior changes such as anxiety, weakened social ability, and repeated stereotyping in the IMH offspring by 40 days.
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