Evidence map›Paper›PMID 38946147›Full record

ArticleJournal of clinical hypertension (Greenwich, Conn.)2024

Association between inflammatory biomarkers and hypertension among sedentary adults in US: NHANES 2009-2018.

Shuo Sha, Xing-Peng Bu, Ai-Wen Wang, Huan-Zhen Chen

Abstract read
In one paragraph

Article in Journal of clinical hypertension (Greenwich, Conn.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Inflammatory Biomarkers in Hypertension.Current medicinal chemistry · 2025
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shuo ShaDepartment of Cardiology, First Hospital of Shangxi Medical University, School of Medicine, Shanxi Medical University, Taiyuan, China.ORCID 0000-0001-6556-4040
Xing-Peng BuDepartment of General Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical, Taiyuan, China.
Ai-Wen WangDepartment of Emergency, The People's Hospital of Changzhi, School of Medicine, Shanxi Medical University, Changzhi, China.
Huan-Zhen ChenDepartment of Cardiology, First Hospital of Shangxi Medical University, School of Medicine, Shanxi Medical University, Taiyuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our study focuses on the relationship between inflammatory biomarkers and hypertension among sedentary adults in the United States, using data from the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2018. We categorized 24,614 participants into two groups based on their daily sedentary time: 9607 individuals in the sedentary group (≥7 h) and 15,007 in the non-sedentary group (<7 h). We found that the sedentary group had a significantly higher prevalence of hypertension than the non-sedentary group. Using weighted multiple logistic regression and smoothing curves, we assessed the correlation between inflammatory biomarkers and hypertension among the sedentary adults. The odds ratios for hypertension were 1.92 for the monocyte to high-density lipoprotein ratio (MHR), 1.15 for the systemic inflammation response index (SIRI), and 1.19 for the natural logarithm of the systemic immune-inflammation index (lnSII), all showing nonlinear associations. Furthermore, a significant positive correlation was found between sedentary time and inflammatory biomarkers (MHR, SIRI, and lnSII). Our findings suggest that prolonged sedentary behavior in the US significantly increases hypertension risk, likely due to marked increases in inflammation markers.

Indexed as

BiomarkersHypertensionInflammationNutrition SurveysSedentary BehaviorAdultAgedCross-Sectional StudiesFemaleHumansLipoproteins, HDLMaleMiddle AgedMonocytesPrevalenceRisk FactorsBiomarkersLipoproteins, HDLhypertensionmonocyte to high‐density lipoprotein ratiosedentary behaviorsystemic immune‐inflammation indexsystemic inflammation response index

Identifiers

PMID38946147
PMCPMC11301436

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.