Evidence map›Paper›PMID 38946128›Full record

ArticleBrain pathology (Zurich, Switzerland)2025

Intracerebellar administration of the chemokine Cxcl3 reduces the volume of medulloblastoma lesions at an advanced stage by promoting the migration and differentiation of preneoplastic precursor cells.

Manuela Ceccarelli, Sabrina Rossi, Fabrizio Bonaventura, Roberto Massari, Annunziata D'Elia, Andrea Soluri, Laura Micheli, Giorgio D'Andrea, Barbara Mancini, Marcello Raspa and 7 more

Abstract read
In one paragraph

Article in Brain pathology (Zurich, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Manuela CeccarelliInstitute of Biochemistry and Cell Biology (IBBC), National Research Council of Italy (CNR), c/o International Campus "A. Buzzati-Traverso", Rome, Italy.ORCID 0000-0001-8741-1600
Sabrina RossiPathology Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.ORCID 0000-0002-1477-8855
Fabrizio BonaventuraPlaisant Srl, Rome, Italy.
Roberto MassariInstitute of Biochemistry and Cell Biology (IBBC), National Research Council of Italy (CNR), c/o International Campus "A. Buzzati-Traverso", Rome, Italy.
Annunziata D'EliaInstitute of Biochemistry and Cell Biology (IBBC), National Research Council of Italy (CNR), c/o International Campus "A. Buzzati-Traverso", Rome, Italy.ORCID 0000-0002-5474-5521
Andrea SoluriInstitute of Biochemistry and Cell Biology (IBBC), National Research Council of Italy (CNR), c/o International Campus "A. Buzzati-Traverso", Rome, Italy.ORCID 0000-0003-4623-6839
Laura MicheliInstitute of Biochemistry and Cell Biology (IBBC), National Research Council of Italy (CNR), c/o International Campus "A. Buzzati-Traverso", Rome, Italy.
Giorgio D'AndreaInstitute of Biochemistry and Cell Biology (IBBC), National Research Council of Italy (CNR), c/o International Campus "A. Buzzati-Traverso", Rome, Italy.
Barbara ManciniPathology Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Marcello RaspaInstitute of Biochemistry and Cell Biology, National Research Council of Italy (IBBC-CNR/EMMA/INFRAFRONTIER/IMPC), c/o International Campus "A. Buzzati-Traverso", Rome, Italy.
Ferdinando ScavizziInstitute of Biochemistry and Cell Biology, National Research Council of Italy (IBBC-CNR/EMMA/INFRAFRONTIER/IMPC), c/o International Campus "A. Buzzati-Traverso", Rome, Italy.
Rita AlaggioPathology Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Francesca Del BufaloOnco-Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Evelina MieleOnco-Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Andrea CaraiNeurosurgery Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Angela MastronuzziOnco-Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Felice TironeInstitute of Biochemistry and Cell Biology (IBBC), National Research Council of Italy (CNR), c/o International Campus "A. Buzzati-Traverso", Rome, Italy.ORCID 0000-0002-0980-4377

Funding

Fondazione Adriano Buzzati-TraversoFondazione Giovanni CeleghinItalian Ministry of Universities and ResearchMinistero della Salute
6 · The paper itself

Abstract

The prognosis for many pediatric brain tumors, including cerebellar medulloblastoma (MB), remains dismal but there is promise in new therapies. We have previously generated a mouse model developing spontaneous MB at high frequency, Ptch1

Indexed as

Cell DifferentiationCell MovementCerebellar NeoplasmsMedulloblastomaAnimalsCerebellumChemokines, CXCDisease Models, AnimalHumansMiceChemokines, CXCcell migrationCxcl3 chemokineCxcr2 receptorhuman biopsiesmedulloblastomamouse models

Identifiers

PMID38946128
PMCPMC11669415

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.