Evidence map›Paper›PMID 38946101›Full record

ReviewExpert review of clinical pharmacology2024

Considerations when prescribing opioid agonist therapies for people living with HIV.

Adati Tarfa, Audun J Lier, Sheela V Shenoi, Sandra A Springer

Abstract readReview
In one paragraph

Review in Expert review of clinical pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Adati TarfaYale AIDS Program, Yale University School of Medicine, New Haven, CT, USA.
Audun J LierInternal Medicine, Renaissance School of Medicine at Stony Brook University, Northport, NY, USA.
Sheela V ShenoiYale AIDS Program, Yale University School of Medicine, New Haven, CT, USA.
Sandra A SpringerYale AIDS Program, Yale University School of Medicine, New Haven, CT, USA.

Funding

Ending HIV: Bringing Integrated Prevention and Treatment Services to People Who Use Drugs Where They LiveDP1DA056106 · NIDA · YALE UNIVERSITY · PI SANDRA Ann SPRINGER · 2022 to 2026
$6.0M
NIDA NIH HHS DP1 DA056106
6 · The paper itself

Abstract

introductionMedications for opioid use disorder (MOUD) include opioid agonist therapies (OAT) (buprenorphine and methadone), and opioid antagonists (extended-release naltrexone). All forms of MOUD improve opioid use disorder (OUD) and HIV outcomes. However, the integration of services for HIV and OUD remains inadequate. Persistent barriers to accessing MOUD underscore the immediate necessity of addressing pharmacoequity in the treatment of OUD in persons with HIV (PWH). AREAS COVERED: In this review article, we specifically focus on OAT among PWH, as it is the most commonly utilized form of MOUD. Specifically, we delineate the intersection of HIV and OUD services, emphasizing their integration into the United States Ending the HIV Epidemic (EHE) plan by offering comprehensive screening, testing, and treatment for both HIV and OUD. We identify potential drug interactions of OAT with antiretroviral therapy (ART), address disparities in OAT access, and present the practical benefits of long-acting formulations of buprenorphine, ART, and pre-exposure prophylaxis for improving HIV prevention and treatment and OUD management. EXPERT OPINION: Optimizing OUD outcomes in PWH necessitates careful attention to diagnosing OUD, initiating OUD treatment, and ensuring medication retention. Innovative approaches to healthcare delivery, such as mobile pharmacies, can integrate both OUD and HIV and reach underserved populations.

Indexed as

Analgesics, OpioidBuprenorphineDrug InteractionsHIV InfectionsMethadoneNaltrexoneNarcotic AntagonistsOpiate Substitution TreatmentOpioid-Related DisordersAnti-HIV AgentsDelayed-Action PreparationsDelivery of Health CareHealth Services AccessibilityHumansPre-Exposure ProphylaxisUnited StatesAnalgesics, OpioidAnti-HIV AgentsBuprenorphineDelayed-Action PreparationsMethadoneNaltrexoneNarcotic AntagonistsBuprenorphineHIVintegrated care modelsmethadonemobile pharmacyMOUDOUDsubstance use disorder

Identifiers

PMID38946101
PMCPMC11299801

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.