Evidence map›Paper›PMID 38945423›Full record

ArticleDevelopmental biology2024

Formin Binding Protein 1 (FNBP1) regulates non-canonical Wnt signaling and vertebrate gastrulation.

Courtney Zeni, Yuko Komiya, Raymond Habas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Heritable Tissue-Specific Gene Expression Associates With Chronic Wound Microbial Species.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Courtney ZeniDepartment of Biology, Temple University, Philadelphia, PA, 19122, USA.
Yuko KomiyaDepartment of Biology, Temple University, Philadelphia, PA, 19122, USA.
Raymond HabasDepartment of Biology, Temple University, Philadelphia, PA, 19122, USA. Electronic address: habas@temple.edu.

Funding

Non-canonical Wnt signaling and cell motilityR01GM078172 · NIGMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI HABAS, RAYMOND · 2007 to 2018
$3.1M
Understanding The Role of Custos in Canonical Wnt SignalingR01GM115929 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI HABAS, RAYMOND · 2015 to 2018
$1.2M
The role of SRGAP2 in vertebrate gastrulation and neural tube closureR03HD082597 · NICHD · TEMPLE UNIV OF THE COMMONWEALTH · PI HABAS, RAYMOND · 2015 to 2016
$155k
Characterization of two proteins that regulate vertebrateR03HD107523 · NICHD · TEMPLE UNIV OF THE COMMONWEALTH · PI HABAS, RAYMOND · 2022 to 2023
$155k
NICHD NIH HHS R03 HD082597NICHD NIH HHS R03 HD107523NIGMS NIH HHS R01 GM078172NIGMS NIH HHS R01 GM115929
6 · The paper itself

Abstract

The Formin protein Daam1 is required for Wnt-induced cytoskeletal changes during gastrulation, though how it accomplishes this remains unresolved. Here we report the characterization of Formin Binding Protein 1 (FNBP1) as a binding partner of Daam1. The interaction of Daam1 with FNBP1 and its domains required for this interaction were delineated. Immunofluorescence studies showed FNBP1 co-localizes with Daam1, and is an integral component of the actin cytoskeletal complex that is responsive to Wnt stimulation. Specifically, FNBP1 can induce intracellular tubule-like structures and localize to focal adhesions suggesting a role for FNBP1 in cell migration. Functional FNBP1 studies in Xenopus embryos uncover a critical role for FNBP1 in regulating vertebrate gastrulation. Additionally, suboptimal doses of Daam1 and FNBP1 synergize to produce severe gastrulation defects, indicating FNBP1 and Daam1 may function within the same signaling pathway. These results together show FNBP1 is an integral component of Daam1-regulated non-canonical Wnt signaling required for vertebrate gastrulation.

Indexed as

GastrulationWnt Signaling PathwayXenopus laevisXenopus ProteinsAdaptor Proteins, Signal TransducingAnimalsCell MovementEmbryo, NonmammalianFatty Acid-Binding ProteinsFemaleHumansMiceMicrofilament ProteinsProtein Bindingrho GTP-Binding ProteinsAdaptor Proteins, Signal TransducingDAAM1 protein, humanDaam1 protein, mouseDaam1 protein, XenopusFatty Acid-Binding ProteinsFNBP1 protein, humanFnbp1 protein, mouseMicrofilament Proteinsrho GTP-Binding ProteinsXenopus Proteins

Identifiers

PMID38945423
PMCPMC11317212

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.