Evidence map›Paper›PMID 38945405›Full record

ArticleJournal of affective disorders2024

Exosome-associated mitochondrial DNA in late-life depression: Implications for cognitive decline in older adults.

Ana Paula Mendes-Silva, Yuliya S Nikolova, Tarek K Rajji, James L Kennedy, Breno S Diniz, Vanessa F Gonçalves, Erica L Vieira

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Premature aging in serious mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ana Paula Mendes-SilvaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Tanenbaum Centre for Pharmacogenetics, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Saskatchewan, Saskatoon, SK, Canada. Electronic address: ana-paula.silva@camh.ca.
Yuliya S NikolovaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Tarek K RajjiDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada; Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.
James L KennedyCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Tanenbaum Centre for Pharmacogenetics, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Breno S DinizUConn Center on Aging & Department of Psychiatry, UConn School of Medicine, University of Connecticut Health Center, USA.
Vanessa F GonçalvesCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Tanenbaum Centre for Pharmacogenetics, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Erica L VieiraCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.

Funding

THE SENDEP STUDY: LINKING MOLECULAR SENESCENCE CHANGES TO DEPRESSION AND COGNITIVE IMPAIRMENT IN LATE LIFER01MH115953 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI DINIZ, BRENO SATLER · 2019 to 2023
$3.0M
NIMH NIH HHS R01 MH115953
6 · The paper itself

Abstract

backgroundDisrupted cellular communication, inflammatory responses and mitochondrial dysfunction are consistently observed in late-life depression (LLD). Exosomes (EXs) mediate cellular communication by transporting molecules, including mitochondrial DNA (EX-mtDNA), playing critical role in immunoregulation alongside tumor necrosis factor (TNF). Changes in EX-mtDNA are indicators of impaired mitochondrial function and might increase vulnerability to adverse health outcomes. Our study examined EX-mtDNA levels and integrity, exploring their associations with levels of TNF receptors I and II (TNFRI and TNFRII), and clinical outcomes in LLD.

methodsNinety older adults (50 LLD and 40 controls (HC)) participated in the study. Blood was collected and exosomes were isolated using size-exclusion chromatography. DNA was extracted and EX-mtDNA levels and deletion were assessed using qPCR. Plasma TNFRI and TNFRII levels were quantified by multiplex immunoassay. Correlation analysis explored relationships between EX-mtDNA, clinical outcomes, and inflammatory markers.

resultsAlthough no differences were observed in EX-mtDNA levels between groups, elevated levels correlated with poorer cognitive performance (r = -0.328, p = 0.002) and increased TNFRII levels (r = 0.367, p = 0.004). LLD exhibited higher deletion rates (F LIMITATION: Cross-sectional study with a small number of participants from a specialized geriatric psychiatry treatment center.

conclusionOur findings suggest that EX-mtDNA holds promise as an indicator of cognitive outcomes in LLD. Additional research is needed to further comprehend the role of EX-mtDNA levels/integrity in LLD, paving the way for its clinical application in the future.

Indexed as

Cognitive DysfunctionDNA, MitochondrialExosomesReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIAgedAged, 80 and overBiomarkersCase-Control StudiesDepressionFemaleHumansMaleBiomarkersDNA, MitochondrialReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IICognitive functionExosomesInflammationLate-life depressionMitochondrial DNA

Identifiers

PMID38945405
PMCPMC11316645

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.