Evidence map›Paper›PMID 38945396›Full record

ArticleMucosal immunology2024

Human intestinal stromal cells promote homeostasis in normal mucosa but inflammation in Crohn's disease in a retinoic acid-deficient manner.

Lesley E Smythies, Olga V Belyaeva, Katie L Alexander, Diane Bimczok, Heidi J Nick, Carolina A Serrano, Kayci R Huff, Marie Nearing, Lois Musgrove, Emily H Poovey and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Retinoic acid in health and disease.Signal transduction and targeted therapy · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Lesley E SmythiesDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: lsmythies@uabmc.edu.
Olga V BelyaevaDepartment of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, AL, USA.
Katie L AlexanderDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Diane BimczokDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, MT, USA.
Heidi J NickDepartment of Pediatrics, National Jewish Health, Denver, CO, USA.
Carolina A SerranoDepartment of Pediatric Gastroenterology and Nutrition, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
Kayci R HuffDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Marie NearingDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Lois MusgroveDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Emily H PooveyDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jaleesa GarthDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Kirk RussDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Kondal R K K BaigDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
David K CrossmanDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.
Shajan PeterDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jamie A CannonDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Charles O ElsonDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Natalia Y KedishviliDepartment of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, AL, USA.
Phillip D SmithDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: pdsmith@uabmc.edu.

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Congenital CMV and CNS Infection Mechanisms of Protective ImmunityR01AI089956 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI William Jarvis Britt · 2011 to 2026
$7.7M
Mucosal HIV and Immunobiology CenterR24DK064400 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SMITH, PHILLIP D · 2003 to 2012
$4.8M
Project-002U01CA260462 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOPPANA, SURESH B, BRITT, WILLIAM JARVIS · 2020 to 2023
$4.0M
EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT: PHYSIOLOGYC06RR020136 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MARCHASE, RICHARD BANFIELD · 2004 to 2004
$3.6M
IMMUNOBIOLOGY AND PREVENTION OF H PYLORI DISEASER01DK054495 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SMITH, PHILLIP D · 1998 to 2009
$2.4M
Short-Chain Dehydrogenases in Retinol/Sterol MetabolismR01AR076924 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KEDISHVILI, NATALIA Y · 2020 to 2024
$2.2M
IMMUNOBIOLOGY OF HIV1 INFECTION IN MUCOSAR01DK047322 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SMITH, PHILLIP D · 1994 to 2007
$2.1M
Dendritic Cell-Epithelial Cell Crosstalk in Human H. pylori GastritisK01DK097144 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BIMCZOK, DIANE · 2012 to 2015
$490k
Role of Gastric Microbiota in Protecting Children from Precancerous Inflammation in H. pylori InfectionR21HD088954 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SMITH, PHILLIP D · 2017 to 2018
$408k
Cytomegalovirus Infection Exacerbates Macrophage-driven Inflammation in Inflammatory Bowel DiseaseR56AI126850 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRITT, WILLIAM JARVIS, SMITH, PHILLIP D · 2018 to 2018
$369k
NCI NIH HHS P30 CA013148NCI NIH HHS U01 CA260462NCRR NIH HHS C06 RR020136NIAID NIH HHS R01 AI089956NIAID NIH HHS R56 AI126850NIAMS NIH HHS R01 AR076924NICHD NIH HHS R21 HD088954NIDDK NIH HHS K01 DK097144NIDDK NIH HHS R01 DK047322NIDDK NIH HHS R01 DK054495NIDDK NIH HHS R24 DK064400
6 · The paper itself

Abstract

Intestinal stromal cells (SCs), which synthesize the extracellular matrix that gives the mucosa its structure, are newly appreciated to play a role in mucosal inflammation. Here, we show that human intestinal vimentin

Indexed as

Crohn DiseaseDendritic CellsHomeostasisIntestinal MucosaStromal CellsTretinoinCell DifferentiationCells, CulturedHumansInflammationTretinoin

Identifiers

PMID38945396
PMCPMC11530961

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.