Evidence map›Paper›PMID 38944813›Full record

ArticleAging2024

Cathepsin L induces cellular senescence by upregulating CUX1 and p16

Yuwei Wu, Danli Jiang, Qing Liu, Shaoyang Yan, Xiuzhen Liu, Ting Wu, Wei Sun, Gang Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Cellular and molecular mechanisms underlying cardiovascular aging.Cellular & molecular biology letters · 2025
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuwei WuDepartment of Cardiology, Third Xiangya Hospital, Central South University, Changsha, China.
Danli JiangAging Institute, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Qing LiuAging Institute, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Shaoyang YanAging Institute, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Xiuzhen LiuAging Institute, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Ting WuDepartment of Cardiology, Third Xiangya Hospital, Central South University, Changsha, China.
Wei SunDepartment of Medicine, Division of Cardiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Gang LiAging Institute, University of Pittsburgh, Pittsburgh, PA 15260, USA.

Funding

Comprehensive functional genomic analysis of the multi-disease associated CDKN2A/B locusR01AG065229 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FINKEL, TOREN, LI, GANG · 2021 to 2025
$2.9M
fSNP-seq and DCP-MS as a New Approach to Study AD-associated, Non-coding Functional SNP's in a Post GWAS EraR01AG056279 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LI, GANG · 2017 to 2019
$1.7M
NIA NIH HHS R01 AG056279NIA NIH HHS R01 AG065229
6 · The paper itself

Abstract

Cathepsin L (CTSL) has been implicated in aging and age-related diseases, such as cardiovascular diseases, specifically atherosclerosis. However, the underlying mechanism(s) is not well documented. Recently, we demonstrated a role of CUT-like homeobox 1 (CUX1) in regulating the p16

Indexed as

Cathepsin LCellular SenescenceCyclin-Dependent Kinase Inhibitor p16Homeodomain ProteinsMuscle, Smooth, VascularRepressor ProteinsAtherosclerosisCells, CulturedEndothelial CellsHumansHuman Umbilical Vein Endothelial CellsMyocytes, Smooth MuscleNuclear ProteinsTranscription FactorsUp-RegulationCathepsin LCDKN2A protein, humanCTSL protein, humanCUX1 protein, humanCyclin-Dependent Kinase Inhibitor p16Homeodomain ProteinsNuclear ProteinsRepressor ProteinsTranscription FactorsatherosclerosisCathepsin LCUX1p16INK4asenescence

Identifiers

PMID38944813
PMCPMC11272106

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.