Evidence map›Paper›PMID 38944161›Full record

ArticleMatrix biology : journal of the International Society for Matrix Biology2024

Loss of 3-O-sulfotransferase enzymes, Hs3st3a1 and Hs3st3b1, reduces kidney and glomerular size and disrupts glomerular architecture.

Vaishali N Patel, James R Ball, Sophie H Choi, Ethan D Lane, Zhangjie Wang, Marit H Aure, Carlos U Villapudua, Changyu Zheng, NIDCD/NIDCR Genomics and Computational Biology Core, Christopher Bleck and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Matrix biology : journal of the International Society for Matrix Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Vaishali N PatelMatrix and Morphogenesis Section, National Institute for Dental and Craniofacial Research, NIH, DHHS, Bethesda, MD, USA. Electronic address: vapatel@nidcr.nih.gov.
James R BallMatrix and Morphogenesis Section, National Institute for Dental and Craniofacial Research, NIH, DHHS, Bethesda, MD, USA.
Sophie H ChoiMatrix and Morphogenesis Section, National Institute for Dental and Craniofacial Research, NIH, DHHS, Bethesda, MD, USA.
Ethan D LaneMatrix and Morphogenesis Section, National Institute for Dental and Craniofacial Research, NIH, DHHS, Bethesda, MD, USA.
Zhangjie WangDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
Marit H AureMatrix and Morphogenesis Section, National Institute for Dental and Craniofacial Research, NIH, DHHS, Bethesda, MD, USA.
Carlos U VillapuduaMatrix and Morphogenesis Section, National Institute for Dental and Craniofacial Research, NIH, DHHS, Bethesda, MD, USA.
Changyu ZhengTranslational Research Core, Nationa Institute of Dental and Craniofacial Research, NIH, DHHS, Bethesda, MD, USA.
NIDCD/NIDCR Genomics and Computational Biology CoreNIDCD/NIDCR Genomics and Computational Biology Core, National Institute for Dental and Craniofacial Research, NIH, DHHS, Bethesda, MD, USA.
Christopher BleckNHLBI Electron Microscopy Core Facility, National Heart, Lung and Blood Institute, NIH, DHHS, Bethesda, MD, USA.
Heba MohammedNHLBI Electron Microscopy Core Facility, National Heart, Lung and Blood Institute, NIH, DHHS, Bethesda, MD, USA.
Zulfeqhar SyedNHLBI Electron Microscopy Core Facility, National Heart, Lung and Blood Institute, NIH, DHHS, Bethesda, MD, USA.
Jian LiuDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
Matthew P HoffmanMatrix and Morphogenesis Section, National Institute for Dental and Craniofacial Research, NIH, DHHS, Bethesda, MD, USA.

Funding

NIDCR DIR Scientific Cores (Combined Technical Research Core)ZICDE000729 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI ABSHARI, MEHRNOOSH · 2009 to 2025
$31.7M
Genomic and Computational Biology Support for NIDCD Intramural ResearchZICDC000086 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI MORELL, ROBERT J · 2015 to 2025
$19.8M
Growth Factor/Extracellular Matrix Interactions During Branching MorphogenesisZIADE000707 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI HOFFMAN, MATTHEW · 2009 to 2023
$14.0M
Progenitor/Stem Cell Function During Salivary Gland DevelopmentZIADE000722 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI HOFFMAN, MATTHEW · 2009 to 2023
$13.7M
Electron Microscopy CoreZICHL005906 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SYED, ZULFEQHAR · 2009 to 2025
$12.9M
Gene Transfer Core, NIDCR-DIRZICDE000744 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI KULKARNI, ASHOK · 2014 to 2023
$12.1M
NIDCR Annual Reports - Veterinary Resources CoreZIGDE000740 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI DAVIDSON, LAUREN · 2012 to 2025
$11.7M
Imaging CoreZICDE000750 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI DOYLE, ANDREW · 2019 to 2025
$6.9M
Development of analytical methods for glycosaminoglycans from biological sourcesR44GM142304 · NIGMS · GLYCAN THERAPEUTICS CORPORATION · PI WANG, ZHANGJIE · 2022 to 2023
$2.0M
Intramural NIH HHS ZIA DE000722Intramural NIH HHS ZIC DC000086Intramural NIH HHS ZIC DE000729Intramural NIH HHS ZIC DE000744Intramural NIH HHS ZIC DE000750Intramural NIH HHS ZIC HL005906Intramural NIH HHS ZIG DE000740NIGMS NIH HHS R44 GM142304
6 · The paper itself

Abstract

Heparan sulfate (HS) is an important component of the kidney anionic filtration barrier, the glomerular basement membrane (GBM). HS chains attached to proteoglycan protein cores are modified by sulfotransferases in a highly ordered series of biosynthetic steps resulting in immense structural diversity due to negatively charged sulfate modifications. 3-O-sulfation is the least abundant modification generated by a family of seven isoforms but creates the most highly sulfated HS domains. We analyzed the kidney phenotypes in the Hs3st3a1, Hs3st3b1 and Hs3st6 -knockout (KO) mice, the isoforms enriched in kidney podocytes. Individual KO mice show no overt kidney phenotype, although Hs3st3b1 kidneys were smaller than wildtype (WT). Furthermore, Hs3st3a1

Indexed as

Kidney GlomerulusMice, KnockoutPodocytesSulfotransferasesAnimalsGlomerular Basement MembraneHeparan SulfateKidneyMiceHeparan SulfateSulfotransferasesGlomerular basement membraneHeparan sulfateHeparan sulfate 3-O-sulfotransferaseKidney

Identifiers

PMID38944161
PMCPMC11402573

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.