Evidence map›Paper›PMID 38943663›Full record

ArticleThe Journal of clinical endocrinology and metabolism2025

Omega-3 Polyunsaturated Fatty Acids And Adipose Tissue Inflammation: Longitudinal Analysis in the PROMISE Cohort.

Ji-Eun Chon, Zhila Semnani-Azad, Kira Zhi Hua Lai, Phillip W Connelly, Ravi Retnakaran, Stewart B Harris, Adam H Metherel, David J A Jenkins, Richard P Bazinet, Anthony J Hanley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Replacement of Soybean Oil withAnimals : an open access journal from MDPI · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ji-Eun ChonDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0009-0005-1625-3285
Zhila Semnani-AzadDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0000-0001-7822-5072
Kira Zhi Hua LaiDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
Phillip W ConnellyKeenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON M5B 1M4, Canada.
Ravi RetnakaranDivision of Endocrinology and Metabolism, University of Toronto, Toronto, ON M5S 3H2, Canada.
Stewart B HarrisDepartment of Family Medicine, Western University, London, ON N6G 2M1, Canada.
Adam H MetherelDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
David J A JenkinsDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0000-0003-1192-9571
Richard P BazinetDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
Anthony J HanleyDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0000-0002-6364-2444

Funding

CIHRDiabetes Canada
6 · The paper itself

Abstract

objectivesAlthough preclinical studies have shown a beneficial impact of omega-3 (n-3) polyunsaturated fatty acids (PUFAs) on adipose tissue (AT) inflammation, the current literature from human studies is limited. Therefore, we aimed to evaluate the longitudinal associations of circulating levels of n-3 PUFAs with biomarkers of AT inflammation.

methodsLongitudinal data from participants in the PROMISE cohort (n = 474) were used. AT inflammation was measured using circulating biomarkers at baseline and up to 2 follow-up visits. n-3 PUFAs were measured at baseline in 4 serum lipid fractions. Generalized estimating equations analyses evaluated longitudinal associations between n-3 PUFAs and AT inflammation, adjusting for covariates.

resultsFully adjusted generalized estimating equation models indicated that higher baseline proportions of eicosapentaenoic acid, n-3 docosapentaenoic acid, and docosahexaenoic acid in total serum were significantly inversely associated with longitudinal change in soluble CD163 (all P < .05). A significant positive association of n-3 docosapentaenoic acid and docosahexaenoic acid with longitudinal change in adiponectin (P < .05) was also observed. Generally consistent associations were observed between n-3 PUFAs and soluble CD163 and adiponectin in the four lipid fractions.

conclusionThese findings will add to the limited evidence on the potential role n-3 PUFAs have in the prevention and management of AT inflammation in humans and may help inform future interventions targeting chronic inflammation at the level of AT.

Indexed as

Adipose TissueFatty Acids, Omega-3InflammationAdultAgedBiomarkersCohort StudiesFatty Acids, UnsaturatedFemaleHumansLongitudinal StudiesMaleMiddle AgedBiomarkersdocosapentaenoic acidFatty Acids, Omega-3Fatty Acids, Unsaturatedadipose tissue inflammationobesityobservationalOmega-3 polyunsaturated fatty acids

Identifiers

PMID38943663
PMCPMC12012786

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.