Evidence map›Paper›PMID 38943616›Full record

ArticleAnalytical chemistry2024

Decoupling Protein Concentration and Aggregate Content Using Diffusion and Water NMR.

Mark I Grimes, Matthew Cheeks, Jennifer Smith, Fabio Zurlo, Mick D Mantle

Abstract read
In one paragraph

Article in Analytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mark I GrimesDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, U.K.ORCID 0000-0001-7655-8156
Matthew CheeksCell Culture & Fermentation Sciences, Biopharmaceutical Development, Biopharmaceuticals R&D, AstraZeneca, Francis Crick Avenue, Cambridge CB2 0AA, U.K.
Jennifer SmithCell Culture & Fermentation Sciences, Biopharmaceutical Development, Biopharmaceuticals R&D, AstraZeneca, Francis Crick Avenue, Cambridge CB2 0AA, U.K.
Fabio ZurloCell Culture & Fermentation Sciences, Biopharmaceutical Development, Biopharmaceuticals R&D, AstraZeneca, Francis Crick Avenue, Cambridge CB2 0AA, U.K.
Mick D MantleDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, U.K.ORCID 0000-0001-7977-3812

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein-based biopharmaceutical drugs, such as monoclonal antibodies, account for the majority of the best-selling drugs globally in recent years. For bioprocesses, key performance indicators are the concentration and aggregate level for the product being produced. In water NMR (

Indexed as

WaterAntibodies, MonoclonalDiffusionMagnetic Resonance SpectroscopyNuclear Magnetic Resonance, BiomolecularProtein AggregatesProteinsAntibodies, MonoclonalProtein AggregatesProteinsWater

Identifiers

PMID38943616
PMCPMC11256015

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.