Evidence map›Paper›PMID 38943182›Full record

ArticleParticle and fibre toxicology2024

Worse pulmonary function in association with cumulative exposure to nanomaterials. Hints of a mediation effect via pulmonary inflammation.

Giulia Squillacioti, Thomas Charreau, Pascal Wild, Valeria Bellisario, Federica Ghelli, Roberto Bono, Enrico Bergamaschi, Giacomo Garzaro, Irina Guseva Canu

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Particle and fibre toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giulia SquillaciotiDepartment of Public Health and Pediatrics, University of Turin, Via Santena 5 bis, 10126, Torino, Italy.
Thomas CharreauDepartment of Occupational and Environmental Health, Center for Primary Care and Public Health (Unisanté), University of Lausanne, Epalinges, Lausanne, 1066, Switzerland.
Pascal WildDepartment of Occupational and Environmental Health, Center for Primary Care and Public Health (Unisanté), University of Lausanne, Epalinges, Lausanne, 1066, Switzerland.
Valeria BellisarioDepartment of Public Health and Pediatrics, University of Turin, Via Santena 5 bis, 10126, Torino, Italy.
Federica GhelliDepartment of Public Health and Pediatrics, University of Turin, Via Santena 5 bis, 10126, Torino, Italy.
Roberto BonoDepartment of Public Health and Pediatrics, University of Turin, Via Santena 5 bis, 10126, Torino, Italy.
Enrico BergamaschiDepartment of Public Health and Pediatrics, University of Turin, Via Santena 5 bis, 10126, Torino, Italy.
Giacomo Garzaro *Department of Public Health and Pediatrics, University of Turin, Via Santena 5 bis, 10126, Torino, Italy.
Irina Guseva Canu *Department of Occupational and Environmental Health, Center for Primary Care and Public Health (Unisanté), University of Lausanne, Epalinges, Lausanne, 1066, Switzerland. irina.guseva-canu@unisante.ch.ORCID 0000-0001-7059-8421

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundToday, nanomaterials are broadly used in a wide range of industrial applications. Such large utilization and the limited knowledge on to the possible health effects have raised concerns about potential consequences on human health and safety, beyond the environmental burden. Given that inhalation is the main exposure route, workers exposed to nanomaterials might be at risk of occurrence of respiratory morbidity and/or reduced pulmonary function. However, epidemiological evidence regarding the association between cumulative exposure to nanomaterials and respiratory health is still scarce. This study focused on the association between cumulative exposure to nanomaterials and pulmonary function among 136 workers enrolled in the framework of the European multicentric NanoExplore project.

resultsOur findings suggest that, independently of lifelong tobacco smoking, ethnicity, age, sex, body mass index and physical activity habits, 10-year cumulative exposure to nanomaterials is associated to worse FEV

conclusionsSafeguarding the respiratory health of workers exposed to nanomaterials should be of primary importance. The observed association between cumulative exposure to nanomaterials and worse pulmonary function parameters underscores the importance of implementing adequate protective measures in the nanocomposite sector. The mitigation of harmful exposures may ensure that workers can continue to contribute productively to their workplaces while preserving their respiratory health over time.

Indexed as

Inhalation ExposureLungNanostructuresOccupational ExposureAdultAir Pollutants, OccupationalCytokinesEuropeFemaleForced Expiratory VolumeHumansMaleMiddle AgedPneumoniaRespiratory Function TestsAir Pollutants, OccupationalCytokinesBiomarkersExhaled breath condensateInflammationNanomaterialsOccupational healthPublic healthPulmonary functionSpirometry

Identifiers

PMID38943182
PMCPMC11212158

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.