Evidence map›Paper›PMID 38943166›Full record

ArticleJournal of cardiothoracic surgery2024

2-year results and myocardial impact of transapical mitral valve repair in patients with primary mitral regurgitation: an echocardiographic study.

Chunqiang Hu, Zhenyi Ge, Wei Li, Wenzhi Pan, Zhengdan Ge, Weipeng Zhao, Dehong Kong, Daxin Zhou, Lai Wei, Xianhong Shu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiothoracic surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Contemporary Transcatheter Approaches to Mitral Regurgitation.Reviews in cardiovascular medicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chunqiang HuDepartment of Echocardiography, Shanghai Institute of Medical Imaging, Shanghai Institute of Cardiovascular Disease, Shanghai, China.
Zhenyi GeDepartment of Echocardiography, Shanghai Institute of Medical Imaging, Shanghai Institute of Cardiovascular Disease, Shanghai, China.
Wei LiDepartment of Echocardiography, Shanghai Institute of Medical Imaging, Shanghai Institute of Cardiovascular Disease, Shanghai, China.
Wenzhi PanDepartment of Cardiology, Shanghai Institute of Cardiovascular Disease, Shanghai, China.
Zhengdan GeDepartment of Echocardiography, Shanghai Institute of Medical Imaging, Shanghai Institute of Cardiovascular Disease, Shanghai, China.
Weipeng ZhaoDepartment of Echocardiography, Shanghai Institute of Medical Imaging, Shanghai Institute of Cardiovascular Disease, Shanghai, China.
Dehong KongDepartment of Echocardiography, Shanghai Institute of Medical Imaging, Shanghai Institute of Cardiovascular Disease, Shanghai, China.
Daxin ZhouDepartment of Cardiology, Shanghai Institute of Cardiovascular Disease, Shanghai, China.
Lai WeiDepartment of Echocardiography, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Xianhong ShuDepartment of Echocardiography, Shanghai Institute of Medical Imaging, Shanghai Institute of Cardiovascular Disease, Shanghai, China.
Cuizhen PanDepartment of Echocardiography, Shanghai Institute of Medical Imaging, Shanghai Institute of Cardiovascular Disease, Shanghai, China. pan.cuizhen@zs-hospital.sh.cn.
Junbo GeDepartment of Cardiology, Shanghai Institute of Cardiovascular Disease, Shanghai, China.

Funding

National Key Research and Development Program of China No. 2020YFC2008104Shanghai Municipal Health Commission No. 202140291
6 · The paper itself

Abstract

backgroundThere is limited data on the 2-year outcomes of transapical transcatheter edge-to-edge repair (TA-TEER) using the ValveClamp in patients with severe primary mitral regurgitation (MR) and its impact on myocardial deformation.

methodsFrom July 2018 to March 2021, 53 patients with symptomatic severe primary MR underwent TA-TEER were enrolled. The endpoint was the composite of all-cause mortality, recurrent 3 + or 4 + MR, or need for mitral surgery.

resultsAmong the 53 patients who had successfully ValveClamp implantation, 8(15.1%) reached the composite endpoint. Significant improvement in left ventricular (LV) end-diastolic volume, pulmonary artery systolic pressure, NYHA functional class, and MR severity were observed (P < 0.05 for all). Univariate Cox's regression analysis revealed that LV end-diastolic volume index, LV end-systolic volume index, left atrial volume index, and pulmonary artery systolic pressure were associated with adverse events (P < 0.05 for all). On multivariate Cox regression analysis, left atrial volume index was independently associated with the endpoint (hazard ratio, 1.049; 95% CI, 1.009-1.091; P < 0.001) after adjustment for above echocardiographic parameters. LV global longitudinal strain and apical longitudinal strain in global and regional segments decreased at 30 days, but showed a recovery at 2 years with no significant difference compared to the baseline.

conclusionTA-TEER using the ValveClamp presented favorable safety and efficacy at 2-year. Myocardial deformation impairment was observed at 30 days post-procedure, but did not persist at 2 years.

Indexed as

Mitral ValveMitral Valve InsufficiencyAgedCardiac CatheterizationEchocardiographyFemaleHeart Valve Prosthesis ImplantationHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeEchocardiographyPrimary mitral regurgitationTranscatheter edge-to-edge repairValveClamp

Identifiers

PMID38943166
PMCPMC11212359

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.