Evidence map›Paper›PMID 38943162›Full record

ArticleThrombosis journal2024

Association of elevated circulating monocyte-platelet aggregates with hypercoagulability in patients with nephrotic syndrome.

Shi-Ping Na, Mei-Liang Ning, Ji-Fang Ma, Shuang Liang, Yan-Li Wang, Man-Shu Sui, Xiao-Fang Guo, Ying Ji, Hui-Yan Lyu, Xue-Ying Yuan and 1 more

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Article in Thrombosis journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

11 authors.

Shi-Ping Na *Department of Nephrology, First Affiliated Hospital of Harbin Medical University, Harbin Medical University, No.23 Youzheng Street, Harbin, 150001, China.
Mei-Liang Ning *Department of Nephrology, First Affiliated Hospital of Harbin Medical University, Harbin Medical University, No.23 Youzheng Street, Harbin, 150001, China.
Ji-Fang MaDepartment of Nephrology, First Affiliated Hospital of Harbin Medical University, Harbin Medical University, No.23 Youzheng Street, Harbin, 150001, China.
Shuang LiangDepartment of Nephrology, First Affiliated Hospital of Harbin Medical University, Harbin Medical University, No.23 Youzheng Street, Harbin, 150001, China.
Yan-Li WangDepartment of Rheumatology, First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, 150001, China.
Man-Shu SuiDepartment of Nephrology, First Affiliated Hospital of Harbin Medical University, Harbin Medical University, No.23 Youzheng Street, Harbin, 150001, China.
Xiao-Fang GuoDepartment of Nephrology, First Affiliated Hospital of Harbin Medical University, Harbin Medical University, No.23 Youzheng Street, Harbin, 150001, China.
Ying JiDepartment of Nephrology, First Affiliated Hospital of Harbin Medical University, Harbin Medical University, No.23 Youzheng Street, Harbin, 150001, China.
Hui-Yan LyuDepartment of Nephrology, First Affiliated Hospital of Harbin Medical University, Harbin Medical University, No.23 Youzheng Street, Harbin, 150001, China.
Xue-Ying YuanDepartment of Nephrology, First Affiliated Hospital of Harbin Medical University, Harbin Medical University, No.23 Youzheng Street, Harbin, 150001, China.
Yu-Shi BaoDepartment of Nephrology, First Affiliated Hospital of Harbin Medical University, Harbin Medical University, No.23 Youzheng Street, Harbin, 150001, China. baoysh@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypercoagulability emerges as a central pathological feature and clinical complication in nephrotic syndrome. Increased platelet activation and aggregability are closely related to hypercoagulability in nephrotic syndrome. Monocyte-platelet aggregates (MPAs) have been proposed to represent a robust biomarker of platelet activation. The aim of this study was to investigate levels of the circulating MPAs and MPAs with the different monocyte subsets to evaluate the association of MPAs with hypercoagulability in nephrotic syndrome.

methodsThirty-two patients with nephrotic syndrome were enrolled. In addition, thirty-two healthy age and sex matched adult volunteers served as healthy controls. MPAs were identified by CD14 monocytes positive for CD41a platelets. The classical (CD14 + + CD16-, CM), the intermediate (CD14 + + CD16+, IM) and the non-classical (CD14 + CD16++, NCM) monocytes, as well as subset specific MPAs, were measured by flow cytometry.

resultsPatients with nephrotic syndrome showed a higher percentage of circulating MPAs as compared with healthy controls (p < 0.001). The percentages of MPAs with CM, IM, and NCM were higher than those of healthy controls (p = 0.012, p < 0.001 and p < 0.001, respectively). Circulating MPAs showed correlations with hypoalbuminemia (r=-0.85; p < 0.001), hypercholesterolemia (r = 0.54; p < 0.001), fibrinogen (r = 0.70; p < 0.001) and D-dimer (r = 0.37; p = 0.003), but not with hypertriglyceridemia in nephrotic syndrome. The AUC for the prediction of hypercoagulability in nephrotic syndrome using MPAs was 0.79 (95% CI 0.68-0.90, p < 0.001). The sensitivity of MPAs in predicting hypercoagulability was 0.71, and the specificity was 0.78.

conclusionIncreased MPAs were correlated with hypercoagulability in nephrotic syndrome. MPAs may serve as a potential biomarker for thrombophilic or hypercoagulable state and provide novel insight into the mechanisms of anticoagulation in nephrotic syndrome.

Indexed as

Hypercoagulable stateMonocyte-platelet aggregatesNephrotic syndromeThrombosis

Identifiers

PMID38943162
PMCPMC11212416

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.