Evidence map›Paper›PMID 38943058›Full record

ArticleBMC cancer2024

MTF1 genetic variants are associated with lung cancer risk in the Chinese Han population.

Yujing Cheng, Chan Zhang, Qi Li, Xin Yang, Wanlu Chen, KunHua He, Mingwei Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yujing ChengDepartment of Respiratory Medicine, The First Affiliated Hospital of School of Medicine of Xi'an Jiaotong University, Yanta District, No. 277, Yanta West Road, Xi'an, 710061, Shaanxi, China.
Chan ZhangDepartment of Blood Transfusion, The First People's Hospital of Yunnan Province, The Afiliated Hospital of Kunming University of Science and Technology, Kunming, 650032, Yunnan, China.
Qi LiDepartment of Blood Transfusion, The First People's Hospital of Yunnan Province, The Afiliated Hospital of Kunming University of Science and Technology, Kunming, 650032, Yunnan, China.
Xin YangDepartment of Blood Transfusion, The First People's Hospital of Yunnan Province, The Afiliated Hospital of Kunming University of Science and Technology, Kunming, 650032, Yunnan, China.
Wanlu ChenDepartment of Blood Transfusion, The First People's Hospital of Yunnan Province, The Afiliated Hospital of Kunming University of Science and Technology, Kunming, 650032, Yunnan, China.
KunHua HeDepartment of Blood Transfusion, The First People's Hospital of Qujing City, Qujing, 655099, Yunnan, China.
Mingwei ChenDepartment of Respiratory Medicine, The First Affiliated Hospital of School of Medicine of Xi'an Jiaotong University, Yanta District, No. 277, Yanta West Road, Xi'an, 710061, Shaanxi, China. mingwei__chen@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetal-regulatory transcription factor 1 (MTF1), a conserved metal-binding transcription factor in eukaryotes, regulates the proliferation of cancer cells by activating downstream target genes and then participates in the formation and progression of tumors, including lung cancer (LC). The expression level of MTF1 is down-regulated in LC, and high expression of MTF1 is associated with a good prognosis of LC. However, the association between MTF1 polymorphism and LC risk has not been explored.

methodsThe genotyping of MTF1 Single nucleotide polymorphisms (SNPs) including rs473279, rs28411034, rs28411352, and rs3748682 was identified by the Agena MassARRAY system among 670 healthy controls and 670 patients with LC. The odds ratio (OR) and 95% confidence intervals (CI) were calculated by logistics regression to assess the association of these SNPs with LC risk.

resultsMTF1 rs28411034 (OR 1.22, 95% CI 1.03-1.45, p = 0.024) and rs3748682 (OR 1.24, 95% CI 1.04-1.47, p = 0.014) were associated with higher LC susceptibility overall. Moreover, the effect of rs28411034 and rs3748682 on LC susceptibility was observed in males, subjects with body mass index (BMI) ≥ 24 kg/m

conclusionsWe were first who reported that rs28411034 and rs3748682 tended to be relevant to increased LC susceptibility among the Chinese Han population. These results of this study could help to recognize the pathogenic mechanisms of the MTF1 gene in LC progress.

Indexed as

DNA-Binding ProteinsGenetic Predisposition to DiseaseLung NeoplasmsPolymorphism, Single NucleotideTranscription Factor MTF-1Transcription FactorsAgedCase-Control StudiesChinaEast Asian PeopleFemaleGenotypeHumansMaleMiddle AgedRisk FactorsDNA-Binding ProteinsMTF1 protein, humanTranscription Factor MTF-1Transcription FactorsClinical featuresDemographic characteristicsLung cancerMTF1 variantsStratification analysisSusceptibility

Identifiers

PMID38943058
PMCPMC11212402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.