Evidence map›Paper›PMID 38943023›Full record

ArticleJournal of neurovirology2024

Induced expression of rabies glycoprotein in the dorsal hippocampus enhances hippocampal dependent memory in a rat model of Alzheimer's disease.

Shayan Aliakbari, Leila Hasanzadeh, Mohammad Sayyah, Niloufar Amini, Hamid Gholami Pourbadie

Abstract read
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In one paragraph

Article in Journal of neurovirology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shayan AliakbariDepartment of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran.
Leila HasanzadehDepartment of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran.
Mohammad SayyahDepartment of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran.
Niloufar AminiDepartment of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran.
Hamid Gholami PourbadieDepartment of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran. gholamipour@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Rabies virus is a neurotropic virus that manipulates the natural cell death processes of its host to ensure its own survival and replication. Studies have shown that the anti-apoptotic effect of the virus is mediated by one of its protein named, rabies glycoprotein (RVG). Alzheimer's disease (AD) is characterized by the loss of neural cells and memory impairment. We aim to examine whether expression of RVG in the hippocampal cells can shield the detrimental effects induced by Aβ. Oligomeric form of Aβ (oAβ) or vehicle was bilaterally microinjected into the dorsal hippocampus of male Wistar rats. One week later, two μl (10

Indexed as

Alzheimer DiseaseDisease Models, AnimalHippocampusRabies virusRats, WistarAmyloid beta-PeptidesAnimalsAvoidance LearningGenetic VectorsGlycoproteinsLentivirusMaleMaze LearningMemoryNeuronsRatsAmyloid beta-PeptidesGlycoproteinsReceptors, AMPAViral Envelope ProteinsAlzheimer’s diseaseAmyloid betaHippocampusLearning and memoryRabies virus

Identifiers

PMID38943023

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.