Evidence map›Paper›PMID 38942931›Full record

Observational studyInternational urogynecology journal2024

A Prospective Observational Study of Posterior Tibial Nerve Stimulation in Multiple Sclerosis.

Giulia Maria Rosa Ippolito, Rita R Palanjian, Yang Mao-Draayer, Aristides Capizzano, Paholo Barboglio-Romo, J Quentin Clemens, Priyanka Gupta, Rodney Dunn, Diana O'Dell, Stephanie Daignault-Newton and 3 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in International urogynecology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Giulia Maria Rosa IppolitoDepartment of Urology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-6977-5280
Rita R PalanjianDepartment of Urology, University of Arizona, Formerly University of Michigan Medical School, Tucson, AZ, USA. ritashehirian@gmail.com.ORCID 0000-0003-4093-6746
Yang Mao-DraayerOklahoma Medical Research Foundation, Formerly Department of Neurology, University of Michigan, Ann Arbor, MI, USA.
Aristides CapizzanoDepartment of Radiology, University of Michigan, Ann Arbor, MI, USA.
Paholo Barboglio-RomoDepartment of Urology, University of Michigan, Ann Arbor, Michigan, USA.
J Quentin ClemensDepartment of Urology, University of Michigan, Ann Arbor, Michigan, USA.
Priyanka GuptaDepartment of Urology, University of Michigan, Ann Arbor, Michigan, USA.
Rodney DunnDepartment of Urology, University of Michigan, Ann Arbor, Michigan, USA.
Diana O'DellDepartment of Anesthesiology, University of Michigan, Formerly Department of Urology, University of Michigan, Ann Arbor, MI, USA.
Stephanie Daignault-NewtonDepartment of Urology, University of Michigan, Ann Arbor, Michigan, USA.
Monica Van TilDepartment of Urology, University of Michigan, Ann Arbor, Michigan, USA.
Anne P CameronDepartment of Urology, University of Michigan, Ann Arbor, Michigan, USA.
John T StoffelDepartment of Urology, University of Michigan, Ann Arbor, Michigan, USA.

Funding

Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction Foundation by K-12 K12-DK111011-06 UroEPI Career Development ProgramSociety of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction Foundation F32 NIDDK Grant F32DK126232Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction Foundation T32 NIDDK Grant T32DK007782
6 · The paper itself

Abstract

introduction and hypothesisThe objective was to examine the outcomes of posterior tibial nerve stimulation (PTNS) on bladder, bowel, and sexual health-related quality of life among a cohort of patients with multiple sclerosis (MS) with refractory lower urinary tract symptoms (LUTS).

methodsPatients with MS and refractory LUTS were recruited for a prospective, observational study using PTNS to treat their symptoms. Patients underwent 12 weekly 30-min PTNS sessions and bladder, bowel, and sexual symptoms were evaluated at baseline, 3, 12, and 24 months with voiding diaries, visual analog scales (VAS), and validated patient-reported questionnaires, including the American Urological Association Symptom Score (AUA-SS), Neurogenic Bladder Symptom Score (NBSS), Michigan Incontinence Symptom Index (M-ISI), Health Status Questionnaire, Sexual Satisfaction Scale, and Bowel Control Scale.

resultsA total of 23 patients were recruited: 18 started PTNS and 14 completed 3 months of PTNS. Of the 18 who started PTNS, the mean age was 52 years (SD 12), 61% were female, 83% were white, and most patients had relapsing remitting (39%) MS. Baseline (n=18) and 3-month voiding (n=11) outcomes showed no significant change in number of voids or incontinence episodes. The median VAS symptom improvement was 49 (IQR 26.5, 26) and 9 (53%) patients elected for monthly maintenance PTNS. On paired analysis, there was a significant improvement in median change in NBSS, AUA-SS, and M-ISI. There was no significant change in bowel or sexual dysfunction.

conclusionsThis prospective, observational study of PTNS in patients with MS with refractory LUTS shows improvement in patient-reported bladder outcomes, but not in number of voids per day or bowel or bladder function.

Indexed as

Lower Urinary Tract SymptomsMultiple SclerosisQuality of LifeTibial NerveAdultElectric Stimulation TherapyFemaleHumansMaleMiddle AgedProspective StudiesSurveys and QuestionnairesTreatment OutcomeLower urinary tract symptomsMultiple sclerosisNeurogenicUrgeUrinary bladderUrinary incontinence

Identifiers

PMID38942931

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.