Evidence map›Paper›PMID 38942828›Full record

ArticleScientific reports2024

Allosteric modulators of M

Corey J Widman, Sestina Ventresca, Jillian Dietrich, Gwendolynne Elmslie, Hazel Smith, Gina Kaup, Aaron Wesley, Madeline Doenecke, Frederick E Williams, Isaac T Schiefer and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Corey J WidmanDepartment of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Mail Stop #1015, 3000 Arlington Ave., Toledo, OH, 43614, USA.
Sestina VentrescaDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, 43614, USA.
Jillian DietrichDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, 43614, USA.
Gwendolynne ElmslieDepartments of Psychiatry and Pharmacology, College of Medicine, Penn State University, Hershey, PA, 17033, USA.
Hazel SmithDepartment of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Mail Stop #1015, 3000 Arlington Ave., Toledo, OH, 43614, USA.
Gina KaupDepartment of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Mail Stop #1015, 3000 Arlington Ave., Toledo, OH, 43614, USA.
Aaron WesleyDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, 43614, USA.
Madeline DoeneckeDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, 43614, USA.
Frederick E WilliamsDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, 43614, USA.
Isaac T SchieferDepartment of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Mail Stop #1015, 3000 Arlington Ave., Toledo, OH, 43614, USA.
John EllisDepartments of Psychiatry and Pharmacology, College of Medicine, Penn State University, Hershey, PA, 17033, USA.
William S MesserDepartment of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Mail Stop #1015, 3000 Arlington Ave., Toledo, OH, 43614, USA. william.messer@utoledo.edu.

Funding

RESPONSES OF SUBPOPULATIONS OF MUSCARINIC RECEPTORSR01AG005214 · NIA · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI ELLIS, JOHN · 1985 to 2011
$2.3M
Responses of Subpopulations of Muscarinic ReceptorsR56AG005214 · NIA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI ELLIS, JOHN · 2017 to 2017
$618k
NIA NIH HHS AG005214NIA NIH HHS R01 AG005214NIA NIH HHS R56 AG005214
6 · The paper itself

Abstract

Allosteric modulation of muscarinic acetylcholine receptors (mAChR) has been identified as a potential strategy for regulating cholinergic signaling in the treatment of various neurological disorders. Most positive allosteric modulators (PAMs) of mAChR enhance agonist affinity and potency, while very few PAMs (e.g., amiodarone) selectively enhance G protein coupling efficacy. The key structural features of amiodarone responsible for enhancement of mAChR efficacy were examined in CHO cells expressing M

Indexed as

AcetylcholineCricetulusLocomotionReceptor, Muscarinic M1ZebrafishAllosteric RegulationAnimalsCHO CellsLigandsMuscarinic AgonistsAcetylcholineLigandsMuscarinic AgonistsReceptor, Muscarinic M1

Identifiers

PMID38942828
PMCPMC11213934

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.