Evidence map›Paper›PMID 38942787›Full record

ArticleScientific reports2024

Increase in methicillin-resistant Staphylococcus spp. colonization among pregnant individuals during COVID-19 pandemic.

A Rio-Tinto, N S Costa, D C S S Alvim, L M A Oliveira, T L R De Oliveira, K R N Dos Santos, S E L Fracalanzza, L M Teixeira, P Marinho, S Taylor and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

A Rio-TintoInstituto de Microbiologia Paulo De Góes, Universidade Federal Do Rio de Janeiro, Rio de Janeiro-RJ, Brazil. andrertmf@micro.ufrj.br.
N S CostaInstituto de Microbiologia Paulo De Góes, Universidade Federal Do Rio de Janeiro, Rio de Janeiro-RJ, Brazil.
D C S S AlvimInstituto de Microbiologia Paulo De Góes, Universidade Federal Do Rio de Janeiro, Rio de Janeiro-RJ, Brazil.
L M A OliveiraInstituto de Microbiologia Paulo De Góes, Universidade Federal Do Rio de Janeiro, Rio de Janeiro-RJ, Brazil.
T L R De OliveiraInstituto de Microbiologia Paulo De Góes, Universidade Federal Do Rio de Janeiro, Rio de Janeiro-RJ, Brazil.
K R N Dos SantosInstituto de Microbiologia Paulo De Góes, Universidade Federal Do Rio de Janeiro, Rio de Janeiro-RJ, Brazil.
S E L FracalanzzaInstituto de Microbiologia Paulo De Góes, Universidade Federal Do Rio de Janeiro, Rio de Janeiro-RJ, Brazil.
L M TeixeiraInstituto de Microbiologia Paulo De Góes, Universidade Federal Do Rio de Janeiro, Rio de Janeiro-RJ, Brazil.
P MarinhoMaternidade Escola da Universidade Federal Do Rio Janeiro, Rio De Janeiro-RJ, Brazil.
S TaylorUK Health Security Agency, London, UK.
S ThomasUK Health Security Agency, London, UK.
T C A PintoInstituto de Microbiologia Paulo De Góes, Universidade Federal Do Rio de Janeiro, Rio de Janeiro-RJ, Brazil.

Funding

Bacterial Vaccines (BactiVac) Network BVNCP4-10Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/211.554/2019Medical Research Council MR/Y033728/1
6 · The paper itself

Abstract

Methicillin-resistant Staphylococcus (MRS) has been associated with neonatal infections, with colonization of the anovaginal tract being the main source of vertical transmission. The COVID-19 pandemic has altered the frequency of antibiotic usage, potentially contributing to changes in the dynamics of bacterial agents colonizing humans. Here we determined MRS colonization rates among pregnant individuals attending a single maternity in Rio de Janeiro, Brazil before (January 2019-March 2020) and during (May 2020-March 2021) the COVID-19 pandemic. Anovaginal samples (n = 806 [521 samples before and 285 during the pandemic]) were streaked onto chromogenic media. Colonies were identified by MALDI-TOF MS. Detection of mecA gene and SCCmec typing were assessed by PCR and antimicrobial susceptibility testing was done according to CLSI guidelines. After the onset of the pandemic, MRS colonization rates increased significantly (p < 0.05) from 8.6% (45) to 54.7% (156). Overall, 215 (26.6%) MRS isolates were detected, of which S. haemolyticus was the most prevalent species (MRSH, 84.2%; 181 isolates). SCCmec type V was the most frequent among MRS (63.3%; 136), and 31.6% (68) of MRS strains had a non-typeable SCCmec, due to new combinations of ccr and mecA complexes. Among MRS strains, 41.9% (90) were resistant to at least 3 different classes of antimicrobial agents, and 60% (54) of them were S. haemolyticus harboring SCCmec V. MRS colonization rates and the emergence of multidrug-resistant variants detected in this study indicate the need for continuing surveillance of this important pathogen within maternal and child populations.

Indexed as

COVID-19Methicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsAdultAnti-Bacterial AgentsBrazilFemaleHumansMicrobial Sensitivity TestsPandemicsPregnancyPregnancy Complications, InfectiousSARS-CoV-2VaginaAnti-Bacterial AgentsAntimicrobial resistanceCOVID-19Methicillin-resistant staphylococciPregnancySCCmec typing

Identifiers

PMID38942787
PMCPMC11213943

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.