Evidence map›Paper›PMID 38942746›Full record

ArticleScientific reports2024

The role of accelerometer-derived sleep traits on glycated haemoglobin and glucose levels: a Mendelian randomization study.

Junxi Liu, Rebecca C Richmond, Emma L Anderson, Jack Bowden, Ciarrah-Jane S Barry, Hassan S Dashti, Iyas S Daghlas, Jacqueline M Lane, Simon D Kyle, Céline Vetter and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Junxi Liu *MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. ieu_james.liu@bristol.ac.uk.
Rebecca C Richmond *MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Emma L AndersonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Jack BowdenMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Ciarrah-Jane S BarryMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Hassan S DashtiCentre for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Iyas S DaghlasCentre for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Jacqueline M LaneCentre for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Simon D KyleSir Jules Thorn Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Céline VetterDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Claire L MorrisonDepartment of Psychology & Neuroscience and Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Samuel E JonesInstitute for Molecular Medicine Finland, University of Helsinki, Uusimaa, Finland.
Andrew R WoodGenetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Timothy M FraylingGenetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Alison K WrightDivision of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Matthew J CarrDivision of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Simon G AndersonGeorge Alleyne Chronic Disease Research Centre, Caribbean Institute of Health Research, University of the West Indies, Kingston, Jamaica.
Richard A EmsleyDepartment of Biostatistics and Health Informatics, King's College London, London, UK.
David W RayOxford Centre for Diabetes, Endocrinology and Metabolism, and Oxford Kavli Centre for Nanoscience Discovery, University of Oxford, Oxford, UK.
Michael N WeedonGenetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Richa SaxenaCentre for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Martin K RutterNIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
Deborah A LawlorMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

Funding

Medical Research Council MR/P023576/1Medical Research Council MR/W019000/1
6 · The paper itself

Abstract

Self-reported shorter/longer sleep duration, insomnia, and evening preference are associated with hyperglycaemia in observational analyses, with similar observations in small studies using accelerometer-derived sleep traits. Mendelian randomization (MR) studies support an effect of self-reported insomnia, but not others, on glycated haemoglobin (HbA1c). To explore potential effects, we used MR methods to assess effects of accelerometer-derived sleep traits (duration, mid-point least active 5-h, mid-point most active 10-h, sleep fragmentation, and efficiency) on HbA1c/glucose in European adults from the UK Biobank (UKB) (n = 73,797) and the MAGIC consortium (n = 146,806). Cross-trait linkage disequilibrium score regression was applied to determine genetic correlations across accelerometer-derived, self-reported sleep traits, and HbA1c/glucose. We found no causal effect of any accelerometer-derived sleep trait on HbA1c or glucose. Similar MR results for self-reported sleep traits in the UKB sub-sample with accelerometer-derived measures suggested our results were not explained by selection bias. Phenotypic and genetic correlation analyses suggested complex relationships between self-reported and accelerometer-derived traits indicating that they may reflect different types of exposure. These findings suggested accelerometer-derived sleep traits do not affect HbA1c. Accelerometer-derived measures of sleep duration and quality might not simply be 'objective' measures of self-reported sleep duration and insomnia, but rather captured different sleep characteristics.

Indexed as

AccelerometryBlood GlucoseGlycated HemoglobinMendelian Randomization AnalysisSleepAdultAgedFemaleHumansMaleMiddle AgedSelf ReportSleep Initiation and Maintenance DisordersBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanDiabetesEpidemiologyGlucoseGlycated haemoglobinMendelian randomizationSleepiness

Identifiers

PMID38942746
PMCPMC11213880

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.