Evidence map›Paper›PMID 38942511›Full record

ArticleMethods in enzymology2024

Brewing coral terpenes-A yeast based approach to soft coral terpene cyclases.

Paul D Scesa, Eric W Schmidt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in enzymology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Diversification of diterpene biosynthesis occurred early in octocoral evolution.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Paul D ScesaDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, UT, United States.
Eric W SchmidtDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, UT, United States. Electronic address: ews1@utah.edu.

Funding

Symbiosis and Chemical Diversity GenerationR35GM148283 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Eric W Schmidt · 2023 to 2026
$2.2M
Elucidating and engineering eleutherobin biosynthesisK99GM148783 · NIGMS · UNIVERSITY OF UTAH · PI SCESA, PAUL DAVID · 2023 to 2024
$250k
NIGMS NIH HHS K99 GM148783NIGMS NIH HHS R35 GM148283
6 · The paper itself

Abstract

Coral terpenes are important molecules with numerous applications. Here, we describe a robust and simple method to produce coral terpene scaffolds at scale. As an example of the approach, here we discover, express, and characterize further klysimplexin R synthases, expanding the known enzymology of soft coral terpene cyclases. We hope that the underlying method described will enable widespread basic research into the functions of coral terpenes and their biosynthetic genes, as well as the commercial development of biomedically and technologically important molecules.

Indexed as

AnthozoaTerpenesAlkyl and Aryl TransferasesAnimalsEscherichia coliSaccharomyces cerevisiaeAlkyl and Aryl TransferasesTerpenesterpene synthaseDiterpenesEleutherobinOctocoral terpenesSaccharomyces expressionSoft coralsTerpene cyclase

Identifiers

PMID38942511
PMCPMC11705981

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.