Evidence map›Paper›PMID 38942338›Full record

ArticleBiochimica et biophysica acta. Molecular basis of disease2024

Upregulation of inflammatory genes and pathways links obesity to severe COVID-19.

Joshua Currey, Calder Ellsworth, Mst Shamima Khatun, Chenxiao Wang, Zheng Chen, Shumei Liu, Cecily Midkiff, Mark Xiao, Mi Ren, Fengming Liu and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Molecular basis of disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Joshua CurreyTulane National Primate Research Center, Covington, LA 70433, USA; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Calder EllsworthTulane National Primate Research Center, Covington, LA 70433, USA; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Mst Shamima KhatunDepartments of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA 70112, USA; Department of Pulmonary Critical Care and Environmental Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Chenxiao WangTulane National Primate Research Center, Covington, LA 70433, USA; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Zheng ChenTulane National Primate Research Center, Covington, LA 70433, USA; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Shumei LiuTulane National Primate Research Center, Covington, LA 70433, USA; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Cecily MidkiffTulane National Primate Research Center, Covington, LA 70433, USA.
Mark XiaoTulane National Primate Research Center, Covington, LA 70433, USA; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Mi RenTulane National Primate Research Center, Covington, LA 70433, USA; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Fengming LiuTulane National Primate Research Center, Covington, LA 70433, USA; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Mona ElgazzazSoutheast Louisiana VA Medical Center, New Orleans, LA 70119, USA.
Sharon FoxSoutheast Louisiana VA Medical Center, New Orleans, LA 70119, USA.
Nicholas J ManessTulane National Primate Research Center, Covington, LA 70433, USA; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Jay RappaportTulane National Primate Research Center, Covington, LA 70433, USA; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Eric LazartiguesSoutheast Louisiana VA Medical Center, New Orleans, LA 70119, USA.
Robert BlairTulane National Primate Research Center, Covington, LA 70433, USA.
Jay K KollsDepartments of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA 70112, USA; Department of Pulmonary Critical Care and Environmental Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Franck Mauvais-JarvisDepartment of Medicine, Section of Endocrinology and Metabolism, Tulane University School of Medicine, New Orleans, LA 70112, USA; Southeast Louisiana VA Medical Center, New Orleans, LA 70119, USA.
Xuebin QinTulane National Primate Research Center, Covington, LA 70433, USA; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA. Electronic address: xqin2@tulane.edu.

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
Training in CD4 T-cell Lung ImmunityR35HL139930 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI KOLLS, JAY K · 2018 to 2024
$6.3M
Targeting the estrogen receptor-α to protect functional β-cell mass in womenR01DK074970 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI Franck Mauvais-Jarvis · 2007 to 2026
$6.0M
Role of Complement Activation in Severe COVID-19R01HL165265 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI QIN, XUEBIN · 2022 to 2025
$2.9M
Renal Macrophage BiologyR01DK129881 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI Xuebin Qin · 2022 to 2026
$2.5M
Impact of Seasonal Variation in Hematocrit, NOx & ET-1 on Vascular ReactivityR21NR010361 · NINR · UNIVERSITY OF MISSOURI-COLUMBIA · PI WIPKE-TEVIS, DEIDRE D · 2008 to 2009
$401k
COVID19: SARS-CoV-2 and ACE2 interaction in hypertensionI01BX005475 · VA · SOUTHEAST LOUISIANA VETERANS HEALTH CARE · PI LAZARTIGUES, ERIC D · 2021 to 2022
–
Role of the Androgen Receptor in Insulin Secretion in the MaleI01BX005812 · VA · SOUTHEAST LOUISIANA VETERANS HEALTH CARE · PI MAUVAIS-JARVIS, FRANCK · 2023 to 2025
–
American Heart Association-American Stroke Association 18PRE34030402American Heart Association-American Stroke Association 962950BLRD VA I01 BX005475BLRD VA I01 BX005812NHLBI NIH HHS R01 HL165265NHLBI NIH HHS R35 HL139930NIDDK NIH HHS R01 DK074970NIDDK NIH HHS R01 DK129881NIH HHS P51 OD011104NINR NIH HHS R21 NR010361
6 · The paper itself

Abstract

Obesity is a risk factor for developing severe COVID-19. However, the mechanism underlying obesity-accelerated COVID-19 remains unclear. Here, we report results from a study in which 2-3-month-old K18-hACE2 (K18) mice were fed a western high-fat diet (WD) or normal chow (NC) over 3 months before intranasal infection with a sublethal dose of SARS-CoV2 WA1 (a strain ancestral to the Wuhan variant). After infection, the WD-fed K18 mice lost significantly more body weight and had more severe lung inflammation than normal chow (NC)-fed mice. Bulk RNA-seq analysis of lungs and adipose tissue revealed a diverse landscape of various immune cells, inflammatory markers, and pathways upregulated in the infected WD-fed K18 mice when compared with the infected NC-fed control mice. The transcript levels of IL-6, an important marker of COVID-19 disease severity, were upregulated in the lung at 6-9 days post-infection in the WD-fed mice when compared to NC-fed mice. Transcriptome analysis of the lung and adipose tissue obtained from deceased COVID-19 patients found that the obese patients had an increase in the expression of genes and the activation of pathways associated with inflammation as compared to normal-weight patients (n = 2). The K18 mouse model and human COVID-19 patient data support a link between inflammation and an obesity-accelerated COVID-19 disease phenotype. These results also indicate that obesity-accelerated severe COVID-19 caused by SARS-CoV-2 WA1 infection in the K18 mouse model would be a suitable model for dissecting the cellular and molecular mechanisms underlying pathogenesis.

Indexed as

COVID-19LungObesitySARS-CoV-2Up-RegulationAdipose TissueAngiotensin-Converting Enzyme 2AnimalsDiet, High-FatDisease Models, AnimalHumansInflammationInterleukin-6MaleMiceSeverity of Illness IndexAngiotensin-Converting Enzyme 2Interleukin-6AdipocytesAnd COVID-19 patientsK18-hACE2 miceObesitySARS-CoV-2Transcriptomics

Identifiers

PMID38942338
PMCPMC11330358

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.