Evidence map›Paper›PMID 38942266›Full record

ArticleExperimental neurology2024

Enhancing cognitive recovery in chronic traumatic brain injury through simultaneous allosteric modulation of α7 nicotinic acetylcholine and α5 GABA

Alyssa F Balleste, Akhila Sangadi, David J Titus, Timothy Johnstone, Derk Hogenkamp, Kelvin W Gee, Coleen M Atkins

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Synaptic Pathology in Traumatic Brain Injury and Therapeutic Insights.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alyssa F BallesteThe Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Akhila SangadiThe Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
David J TitusDepartment of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.
Timothy JohnstoneDepartment of Pharmacology, University of Arizona, Tucson, USA.
Derk HogenkampDepartment of Pharmaceutical Sciences, University of California Irvine, Irvine, USA.
Kelvin W GeeDepartment of Pharmaceutical Sciences, University of California Irvine, Irvine, USA.
Coleen M AtkinsThe Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: catkins@miami.edu.

Funding

Rehabilitation Strategies for Memory Dysfunction After Traumatic Brain InjuryR01NS069721 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ATKINS, COLEEN M. · 2010 to 2019
$3.7M
NINDS NIH HHS R01 NS069721
6 · The paper itself

Abstract

Traumatic brain injury (TBI) leads to changes in the neural circuitry of the hippocampus that result in chronic learning and memory deficits. However, effective therapeutic strategies to ameliorate these chronic learning and memory impairments after TBI are limited. Two pharmacological targets for enhancing cognition are nicotinic acetylcholine receptors (nAChRs) and GABA

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorBrain Injuries, TraumaticRats, Sprague-DawleyReceptors, GABA-AAllosteric RegulationAnimalsHippocampusLong-Term PotentiationMaleRatsRecovery of Functionalpha7 Nicotinic Acetylcholine ReceptorChrna7 protein, ratGabra5 protein, ratReceptors, GABA-ACognitionFluid percussion injuryHippocampusMemoryTraumatic brain injuryα5 GABA(A) receptorα7 nicotinic acetylcholine receptor

Identifiers

PMID38942266
PMCPMC11283977

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.