Evidence map›Paper›PMID 38942238›Full record

ArticleJournal of neuroscience methods2024

Integrated Short-TE and Hadamard-edited Multi-Sequence (ISTHMUS) for advanced MRS.

Steve C N Hui, Saipavitra Murali-Manohar, Helge J Zöllner, Kathleen E Hupfeld, Christopher W Davies-Jenkins, Aaron T Gudmundson, Yulu Song, Vivek Yedavalli, Jessica L Wisnowski, Borjan Gagoski and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience methods, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Identifying out-of-voxel echoes in edited MRS with phase cycle inversion.bioRxiv : the preprint server for biology · 2025
    Article
  6. Review
  7. Article
  8. Pitfalls in 2HG Detection With TE-Optimized MRS at 3T.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Steve C N HuiDeveloping Brain Institute, Children's National Hospital, Washington, D.C., USA; Department of Radiology, The George Washington University School of Medicine and Health Sciences, Washington, D.C., USA; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, D.C., USA.
Saipavitra Murali-ManoharThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Helge J ZöllnerThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Kathleen E HupfeldThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Christopher W Davies-JenkinsThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Aaron T GudmundsonThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Yulu SongThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Vivek YedavalliThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Jessica L WisnowskiDepartment of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA; Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Borjan GagoskiFetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA.
Georg OeltzschnerThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Richard A E EddenThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA. Electronic address: raee2@jhu.edu.

Funding

The Healthy Brain and Child Development National Consortium Administrative CoreU24DA055325 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHRISTINA CHAMBERS, CHARLES Alexander NELSON · 2021 to 2026
$40.8M
TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Peter CM Van Zijl · 2021 to 2026
$9.9M
2/24 Healthy Brain and Child Development National ConsortiumU01DA055362 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI PAT LEVITT, Beth A Smith · 2021 to 2026
$9.6M
Universal GABA-edited MRS at 3TR01EB016089 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2013 to 2026
$5.4M
Simultaneous Hadamard Editing of GABA and GlutathioneR01EB023963 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2017 to 2024
$3.8M
Edited Magnetic Resonance Spectroscopy of the Pediatric BrainR01EB032788 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2023 to 2026
$2.7M
Towards a comprehensive neurometabolic profile in patients with mild cognitive impairment.R00AG062230 · NIA · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2021 to 2023
$735k
Validating MRS lipids as biomarkers of brain injury in neonates with hypoxic-ischemic encephalopathyK23HD099309 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI WISNOWSKI, JESSICA L · 2019 to 2023
$693k
General Linear Modeling For Magnetic Resonance SpectroscopyR21EB033516 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2022 to 2024
$670k
Cortical Inhibition and Mobility in Older AdultsK00AG068440 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUPFELD, KATHLEEN ELIZABETH · 2022 to 2024
$222k
Brain metabolism across the lifespan using multi-parametric MRSK99AG080084 · NIA · JOHNS HOPKINS UNIVERSITY · PI ZOELLNER, HELGE JOERN · 2023 to 2024
$212k
NIA NIH HHS K00 AG068440NIA NIH HHS K99 AG080084NIA NIH HHS R00 AG062230NIBIB NIH HHS P41 EB031771NIBIB NIH HHS R01 EB016089NIBIB NIH HHS R01 EB023963NIBIB NIH HHS R01 EB032788NIBIB NIH HHS R21 EB033516NICHD NIH HHS K23 HD099309NIDA NIH HHS U01 DA055362NIDA NIH HHS U24 DA055325
6 · The paper itself

Abstract

backgroundTo examine data quality and reproducibility using ISTHMUS, which has been implemented as the standardized MR spectroscopy sequence for the multi-site Healthy Brain and Child Development (HBCD) study.

methodsISTHMUS is the consecutive acquisition of short-TE PRESS (32 transients) and long-TE HERCULES (224 transients) data with dual-TE water reference scans. Voxels were positioned in the centrum semiovale, dorsal anterior cingulate cortex, posterior cingulate cortex and bilateral thalamus regions. After acquisition, ISTHMUS data were separated into the PRESS and HERCULES portions for analysis and modeled separately using Osprey. In vivo experiments were performed in 10 healthy volunteers (6 female; 29.5±6.6 years). Each volunteer underwent two scans on the same day. Differences in metabolite measurements were examined. T

resultsNo significant difference in linewidth was observed between PRESS and HERCULES. Bilateral thalamus spectra had produced significantly higher (p<0.001) linewidth compared to the other three regions. Linewidth measurements were similar between scans, with scan-to-scan differences under 1 Hz for most subjects. Paired t-tests indicated a significant difference only in PRESS NAAG between the two thalamus scans (p=0.002). T

conclusionsISTHMUS facilitated data acquisition and post-processing and reduced operator workload to eliminate potential human error.

Indexed as

Magnetic Resonance SpectroscopyAdultBrainFemaleGray MatterHumansMagnetic Resonance ImagingMaleReproducibility of ResultsWhite MatterYoung AdultHadamard encodingHBCDMR spectroscopyPRESSSpectral editing

Identifiers

PMID38942238
PMCPMC11286357

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