Evidence map›Paper›PMID 38942073›Full record

ArticleJournal of molecular and cellular cardiology2024

Development and characterization of the mode-of-action of inhibitory and agonist peptides targeting the voltage-gated sodium channel SCN1B beta-subunit.

Zachary J Williams, Anita Alvarez-Laviada, Daniel Hoagland, L Jane Jourdan, Steven Poelzing, Julia Gorelik, Robert G Gourdie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zachary J WilliamsFralin Biomedical Research Institute, Virginia Polytechnic University, Roanoke, VA, United States.
Anita Alvarez-LaviadaDepartment of Myocardial Function, Imperial College London, London, United Kingdom.
Daniel HoaglandFralin Biomedical Research Institute, Virginia Polytechnic University, Roanoke, VA, United States.
L Jane JourdanFralin Biomedical Research Institute, Virginia Polytechnic University, Roanoke, VA, United States.
Steven PoelzingFralin Biomedical Research Institute, Virginia Polytechnic University, Roanoke, VA, United States; School of Medicine, Virgina Polytechnic University, Roanoke, VA, United States; Department of Biomedical Engineering and Mechanics, Virginia Polytechnic University, Roanoke, VA, United States.
Julia GorelikDepartment of Myocardial Function, Imperial College London, London, United Kingdom.
Robert G GourdieFralin Biomedical Research Institute, Virginia Polytechnic University, Roanoke, VA, United States; School of Medicine, Virgina Polytechnic University, Roanoke, VA, United States; Department of Biomedical Engineering and Mechanics, Virginia Polytechnic University, Roanoke, VA, United States. Electronic address: gourdier@vtc.vt.edu.

Funding

PATTERNING OF GAP JUNCTION COUPLING IN DEVELOPING HEARTR01HL056728 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI GOURDIE, ROBERT G · 1997 to 2021
$5.6M
Connexin-based Signaling in the Heart: Cellular and ExosomalR35HL161237 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI ROBERT G GOURDIE · 2022 to 2026
$4.4M
Role of the Extracellular Space as a Modulator of the Cardiac Gap Junction - Conduction Velocity RelationshipR01HL102298 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI POELZING, STEVEN · 2011 to 2020
$3.9M
Signaling in Inherited and Acquired Sodium Channel Gain of FunctionR01HL138003 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI POELZING, STEVEN, WEINBERG, SETH HOWARD · 2018 to 2021
$2.6M
The Role of the Sodium Channel Beta Subunit in Cardiac ConductionR01HL141855 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI GOURDIE, ROBERT G, POELZING, STEVEN · 2018 to 2021
$1.8M
The Effects of the SCN1B Mimetic Peptide Badp1 on the Regulated Intramembrane Proteolysis PathwayF31HL164088 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI WILLIAMS, ZACHARY · 2022 to 2023
$67k
NHLBI NIH HHS F31 HL164088NHLBI NIH HHS R01 HL056728NHLBI NIH HHS R01 HL102298NHLBI NIH HHS R01 HL138003NHLBI NIH HHS R01 HL141855NHLBI NIH HHS R35 HL161237
6 · The paper itself

Abstract

Cardiac arrhythmia treatment is a clinical challenge necessitating safer and more effective therapies. Recent studies have highlighted the role of the perinexus, an intercalated disc nanodomain enriched in voltage-gated sodium channels including both Na

Indexed as

Myocytes, CardiacPeptidesVoltage-Gated Sodium Channel beta-1 SubunitAction PotentialsAnimalsCell AdhesionHumansRatsPeptidesVoltage-Gated Sodium Channel beta-1 SubunitArrhythmiaPeptide therapeuticSCN1B (β1/β1B)Voltage-gated sodium channels

Identifiers

PMID38942073
PMCPMC11647768

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.