ArticleCell genomics2024
Evolutionary and biomedical implications of sex differences in the primate brain transcriptome.
Article in Cell genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Expression patterns of risk genes associated with three evolutionarily relevant syndromes in rhesus macaque and human brains.Translational psychiatry · 2026Article
- Inflammatory mechanisms underlying early Alzheimer's disease pathology: evidence from the aging rhesus macaque brain.Frontiers in cellular neuroscience · 2026Review
- Single-cell, multi-region profiling of the macaque brain across the lifespan.bioRxiv : the preprint server for biology · 2025Article
- Early establishment and life course stability of sex biases in the human brain transcriptome.Cell genomics · 2025Article
- Sex Differences in Brain Transcriptomes of Juvenile Cynomolgus Macaques.Biomolecules · 2025Article
- A Natural Disaster Exacerbates and Redistributes Disease Risk Among Free-Ranging Macaques by Altering Social Structure.Ecology letters · 2025Article
- Rhesus macaque as a model for sex-biased neurological diseases.Cell genomics · 2024Article
- The biology of aging in a social world: Insights from free-ranging rhesus macaques.Neuroscience and biobehavioral reviews · 2023Review
- The biology of aging in a social world:insights from free-ranging rhesus macaques.bioRxiv : the preprint server for biology · 2023Article
- Multiregion transcriptomic profiling of the primate brain reveals signatures of aging and the social environment.Nature neuroscience · 2022Article
Corrections and comments
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Authors and funding
21 authors.
Funding
Abstract
Humans exhibit sex differences in the prevalence of many neurodevelopmental disorders and neurodegenerative diseases. Here, we generated one of the largest multi-brain-region bulk transcriptional datasets for the rhesus macaque and characterized sex-biased gene expression patterns to investigate the translatability of this species for sex-biased neurological conditions. We identify patterns similar to those in humans, which are associated with overlapping regulatory mechanisms, biological processes, and genes implicated in sex-biased human disorders, including autism. We also show that sex-biased genes exhibit greater genetic variance for expression and more tissue-specific expression patterns, which may facilitate rapid evolution of sex-biased genes. Our findings provide insights into the biological mechanisms underlying sex-biased disease and support the rhesus macaque model for the translational study of these conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.