Evidence map›Paper›PMID 38942017›Full record

ArticleDevelopmental cell2024

The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells.

Tihana Trsan, Vincent Peng, Chirag Krishna, Takahiro E Ohara, Wandy L Beatty, Raki Sudan, Masahiro Kanai, Praveen Krishnamoorthy, Patrick Fernandes Rodrigues, Jose L Fachi and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Tihana TrsanDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Vincent PengDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Chirag KrishnaCenter for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Takahiro E OharaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Wandy L BeattyDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Raki SudanDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Masahiro KanaiCenter for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Praveen KrishnamoorthyWashington University Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO 63110, USA.
Patrick Fernandes RodriguesDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Jose L FachiDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Gary Grajales-ReyesDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Natalia JaegerDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
James A J FitzpatrickWashington University Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO 63110, USA; Departments of Cell Biology & Physiology and Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63110, USA.
Marina CellaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Susan GilfillanDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Toru NakataCenter for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Alok JaiswalCenter for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Thaddeus S StappenbeckDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Mark J DalyBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Ramnik J XavierCenter for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: xavier@molbio.mgh.harvard.edu.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: mcolonna@wustl.edu.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
Systematic dissection of gut cellular circuits [at single cell resolution]RC2DK114784 · NIDDK · BROAD INSTITUTE, INC. · PI ASHENBERG, ORR, GRAHAM, DANIEL BARTHOLOMEW · 2017 to 2021
$9.0M
ATG16L1 T300A: genetics to biologyR01DK097485 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI XAVIER, RAMNIK J · 2013 to 2021
$4.1M
Mucosal Immune Defense Mechanisms of the Urinary BladderR01DK132327 · NIDDK · WASHINGTON UNIVERSITY · PI MARCO COLONNA, SCOTT J. HULTGREN · 2023 to 2026
$2.5M
Lysosome Homeostasis and Microbicidal Mechanisms in Innate ImmunityR01DK117263 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI XAVIER, RAMNIK J · 2018 to 2021
$2.4M
ZEISS LSM880 AIRYSCAN MICROSCOPE FOR SHARED BIOMEDICAL RESEARCHS10OD021629 · OD · WASHINGTON UNIVERSITY · PI FITZPATRICK, JAMES ALEXANDER · 2017 to 2017
$596k
NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NCI NIH HHS P30 CA91842NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R01 DK097485NIDDK NIH HHS R01 DK117263NIDDK NIH HHS R01 DK132327NIDDK NIH HHS RC2 DK114784NIH HHS S10 OD021629
6 · The paper itself

Abstract

Recent advances in human genetics have shed light on the genetic factors contributing to inflammatory diseases, particularly Crohn's disease (CD), a prominent form of inflammatory bowel disease. Certain risk genes associated with CD directly influence cytokine biology and cell-specific communication networks. Current CD therapies primarily rely on anti-inflammatory drugs, which are inconsistently effective and lack strategies for promoting epithelial restoration and mucosal balance. To understand CD's underlying mechanisms, we investigated the link between CD and the FGFR1OP gene, which encodes a centrosome protein. FGFR1OP deletion in mouse intestinal epithelial cells disrupted crypt architecture, resulting in crypt loss, inflammation, and fatality. FGFR1OP insufficiency hindered epithelial resilience during colitis. FGFR1OP was crucial for preserving non-muscle myosin II activity, ensuring the integrity of the actomyosin cytoskeleton and crypt cell adhesion. This role of FGFR1OP suggests that its deficiency in genetically predisposed individuals may reduce epithelial renewal capacity, heightening susceptibility to inflammation and disease.

Indexed as

Epithelial CellsIntestinal MucosaMyosin Type IIActomyosinAnimalsCell AdhesionCentrosomeColitisCrohn DiseaseHumansInflammationMiceMice, Inbred C57BLActomyosinMyosin Type IIadhesionautoimmunitycentrosomecytoskeletondesmosomeepithelial cellsFGFR1OPinflammatory bowel diseasenon-muscle myosin

Identifiers

PMID38942017
PMCPMC11421975

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.