Evidence map›Paper›PMID 38941871›Full record

ArticleComprehensive psychiatry2024

We've all been wrong about provisional tic disorder.

Sarah C Grossen, Amanda L Arbuckle, Emily C Bihun, Jonathan M Koller, David Y Song, Angela M Reiersen, Bradley L Schlaggar, Deanna J Greene, Kevin J Black

Abstract read
In one paragraph

Article in Comprehensive psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Tourette syndrome.Nature reviews. Disease primers · 2026
    Review
  2. Review
  3. Article
  4. Social context is a cue for tic reduction in clinical settings.European child & adolescent psychiatry · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sarah C GrossenDepartments of Psychiatry and Neurology, Washington University in St. Louis, St. Louis, MO, United States of America.
Amanda L ArbuckleDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, United States of America.
Emily C BihunDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, United States of America.
Jonathan M KollerDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, United States of America.
David Y SongDepartments of Psychiatry and Neurology, Washington University in St. Louis, St. Louis, MO, United States of America.
Angela M ReiersenDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, United States of America.
Bradley L SchlaggarKennedy Krieger Institute, Baltimore, MD, and Departments of Neurology and Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
Deanna J GreeneDepartment of Cognitive Science, University of California San Diego, La Jolla, CA, United States of America.
Kevin J BlackDepartments of Psychiatry, Neurology, Radiology, and Neuroscience, Washington University in St. Louis, St. Louis, MO, United States of America. Electronic address: kevin@wustl.edu.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Intellectual and Developmental Disabilities Research Center-Administrative Down Syndrome SupplementU54HD087011 · NICHD · WASHINGTON UNIVERSITY · PI MOLEY, KELLE H · 2015 to 2019
$7.1M
The New Tics Study: A Novel Approach to Pathophysiology and Cause of Tic DisordersR01MH104030 · NIMH · WASHINGTON UNIVERSITY · PI BLACK, KEVIN J · 2017 to 2021
$3.3M
Longitudinal Study of Brain Imaging and Cognitive Markers of Tourette Syndrome in ChildrenR01MH118217 · NIMH · WASHINGTON UNIVERSITY · PI GREENE, DEANNA JACQUELYN · 2019 to 2025
$3.2M
Unilateral Hearing Loss in ChildrenK23DC006638 · NIDCD · WASHINGTON UNIVERSITY · PI LIEU, JUDITH EUNKYUNG CHO · 2005 to 2009
$886k
Training New Investigators in Neuroimaging and in the Neuropsychiatry of MovementK24MH087913 · NIMH · WASHINGTON UNIVERSITY · PI BLACK, KEVIN J · 2010 to 2014
$818k
PREDICTING OUTCOME IN CHILDREN WITH TIC DISORDERS USING NEUROIMAGING DATAK01MH104592 · NIMH · WASHINGTON UNIVERSITY · PI GREENE, DEANNA JACQUELYN · 2014 to 2018
$723k
PREDICTING OUTCOME IN CHILDREN WITH NEW-ONSET TICS USING NEUROIMAGING DATAR21NS091635 · NINDS · WASHINGTON UNIVERSITY · PI BLACK, KEVIN J, SCHLAGGAR, BRADLEY L · 2015 to 2016
$419k
NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NCRR NIH HHS UL1 RR024992NICHD NIH HHS U54 HD087011NIDCD NIH HHS K23 DC006638NIMH NIH HHS K01 MH104592NIMH NIH HHS K24 MH087913NIMH NIH HHS R01 MH104030NIMH NIH HHS R01 MH118217NINDS NIH HHS R21 NS091635
6 · The paper itself

Abstract

backgroundProvisional Tic Disorder (PTD) is common in childhood. The received wisdom among clinicians is that PTD is short-lived and mild, with at most a few tics, and rarely includes complex tics, premonitory phenomena or comorbid illnesses. However, such conclusions come from clinical experience, with biased ascertainment and limited follow-up.

methodsProspective study of 89 children with tics starting 0-9 months ago (median 4 months), fewer than half from clinical sources. Follow-up at 12 (± 24, 36, 48) months after the first tic.

resultsAt study entry, many children had ADHD (39), an anxiety disorder (27), OCD (9) or enuresis (17). All had at least two current tics, with a mean total since onset of 6.9 motor and 2.0 phonic tics. Forty-one had experienced a complex tic, and 69 could suppress some tics. Tics were clinically meaningful: 64 had tics severe enough for a clinical trial, and 76 families sought medical attention for the tics. At 12 months, 79 returned, and 78 still had tics. Of these, 29 manifested no tics during history and extended examination, but only via audio-visual monitoring when the child was seated alone. Only 12/70 now had plans to see a doctor for tics. Most who returned at 2-4 years still had tics known to the child and family, but medical impact was low.

conclusionsOur results do not contradict previous data, but overturn clinical lore. The data strongly argue against the longstanding but arbitrary tradition of separating tic disorders into recent-onset versus chronic.

Indexed as

Tic DisordersAdolescentAnxiety DisordersAttention Deficit Disorder with HyperactivityChildChild, PreschoolComorbidityEnuresisFemaleFollow-Up StudiesHumansMaleObsessive-Compulsive DisorderProspective StudiesProvisional Tic DisorderTic disorders/classification (MeSH)Tic disorders/psychology (MeSH)Tourette syndrome (MeSH)

Identifiers

PMID38941871
PMCPMC11373539

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.