Evidence map›Paper›PMID 38941842›Full record

Observational studyJournal of biomechanics2024

Dynamic gait stability and stability symmetry for people with transfemoral amputation: A case-series of 19 individuals with bone-anchored limbs.

James B Tracy, Brecca M M Gaffney, Peter B Thomsen, Mohamed E Awad, Danielle H Melton, Cory L Christiansen, Jason W Stoneback

Abstract readObservational Study
In one paragraph

Observational study in Journal of biomechanics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

James B TracyDepartment of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Veteran's Affairs Eastern Colorado Healthcare System, Aurora, CO, USA. Electronic address: james.tracy@cuanschutz.edu.
Brecca M M GaffneyVeteran's Affairs Eastern Colorado Healthcare System, Aurora, CO, USA; Department of Mechanical Engineering, University of Colorado Denver, Denver, CO, USA; Center for Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Peter B ThomsenDepartment of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Veteran's Affairs Eastern Colorado Healthcare System, Aurora, CO, USA.
Mohamed E AwadDepartment of Orthopedics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Danielle H MeltonDepartment of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Orthopedics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Cory L ChristiansenDepartment of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Veteran's Affairs Eastern Colorado Healthcare System, Aurora, CO, USA.
Jason W StonebackDepartment of Orthopedics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Effect of Osseointegrated Prostheses on the Pathogenesis of Hip Osteoarthritis in Patients with Lower Limb LossK01AR080776 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Brecca Gaffney · 2023 to 2026
$522k
Dynamic Bone-Implant Loading in Osseointegrated ProsthesesR03HD111012 · NICHD · UNIVERSITY OF COLORADO DENVER · PI GAFFNEY, BRECCA · 2023 to 2024
$289k
NCATS NIH HHS UL1 TR002535NIAMS NIH HHS K01 AR080776NICHD NIH HHS R03 HD111012
6 · The paper itself

Abstract

For some individuals with severe socket-related problems, prosthesis osseointegration directly connects a prosthesis to the residual limb creating a bone-anchored limb (BAL). We compared dynamic gait stability and between-limb stability symmetry, as measured by the Margin of Stability (MoS) and the Normalized Symmetry Index (NSI), for people with unilateral transfemoral amputation before and one-year after BAL implantation. The MoS provides a mechanical construct to assess dynamic gait stability and infer center of mass and limb control by relating the center of mass and velocity to the base of support. Before and one-year after BAL implantation, 19 participants walked overground at self-selected speeds. We quantified dynamic gait stability anteriorly and laterally at foot strike and at the minimum lateral MoS value. After implantation, we observed decreased lateral MoS at foot strike for the amputated (MoS mean(SD) %height; pre: 6.6(2.3), post: 5.9(1.3), d = 0.45) and intact limb (pre: 6.2(1.2), post: 5.8(1.0), d = 0.38) and increased between-limb MoS symmetry at foot strike (NSI mean(SD) %; anterior-pre: 10.3(7.3), post: 8.4(3.6), d = 0.23; lateral-pre: 18.8(12.4), post: 12.4(4.9), d = 0.47) and at minimum lateral stability (pre: 28.1(18.1), post: 19.2(6.8), d = 0.50). Center of mass control using a BAL resulted in dynamic gait stability more similar between limbs and may have reduced the adoption of functional asymmetries. We suggest that improved between-limb MoS symmetry after BAL implantation is likely due to subtle changes in individual limb MoS values at self-selected walking speeds resulting in an overall positive impact on fall risk through improved center of mass and prosthetic limb control.

Indexed as

Amputation, SurgicalArtificial LimbsBone-Anchored ProsthesisFemurFunctional LateralityGaitAdultAgedFemaleFootHumansMaleOsseointegrationPostoperative PeriodPostural BalanceTime FactorsMargin of StabilityOsseointegrationPostural ControlProstheticWalking

Identifiers

PMID38941842
PMCPMC11251498

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.