ArticleThe Plant cell2024
Alternative splicing of a potato disease resistance gene maintains homeostasis between growth and immunity.
Article in The Plant cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Surface immunity releases an RNA-encoded safety lock on NLR activation.Science China. Life sciences · 2026Article
- A guardian angel: how immune factor RPS2 is activated by pathogen effector AvrRpt2.The Plant cell · 2026Article
- Chemical treatment rescues reduced growth of the autoimmune mutant chs3-2D without compromising its immune responses.Plant biology (Stuttgart, Germany) · 2026Article
- RNA regulation in plants.Science China. Life sciences · 2026Review
- Teamwork makes the dream work: IPA1 and OsNPR1 work together to enhance immunity in rice.The Plant cell · 2026Article
- GmSNAP14: a key contributor to soybean cyst nematode resistance in soybean.The New phytologist · 2026Article
- Exploiting plant immune "switches" for resistance engineering.Stress biology · 2026Review
- Genomic basis underlying alternative transcripts-mediated drought tolerance in maize.Genome biology · 2026Article
- Alternative splicing: an underexplored layer in immune receptor regulation, systemic resistance and priming.Frontiers in plant science · 2026Article
- Alternative splicing in plant stress responses: potential application for crop improvement.Planta · 2025Review
- Malate metabolism in horticultural crops: mechanistic insights and agricultural practices for quality improvement.Molecular horticulture · 2025Review
- RNA-binding proteins orchestrating immunity in plants.The Plant journal : for cell and molecular biology · 2025Review
- Solanum bulbocastanum nucleotide-binding leucine-rich repeat receptor evolution reveals functional variants and critical residues in Rpi-blb1/RB.Journal of integrative plant biology · 2025Article
- U11/U12 Small Nuclear Ribonucleoprotein TaU11/U12-35K Interacts with TaHis and Negatively Contributes to Fusarium Head Blight Resistance in Wheat.International journal of molecular sciences · 2025Article
- Dynamic Coordination of Alternative Splicing and Subgenome Expression Bias Underlies Rusty Root Symptom Response inPlants (Basel, Switzerland) · 2025Article
- A Phase-Separated SR Protein Reprograms Host Pre-mRNA Splicing to Enhance Disease Susceptibility.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Quantitive disease resistance (QDR): The alternative to "all-or-nothing" strategy in plant immunity.The Plant cell · 2025Article
- Local and systemic transcriptome and spliceome reprogramming induced by the root-knot nematodeHorticulture research · 2024Article
- Chloroplast-actin filaments decide the direction of chloroplast avoidance movement under strong light in Arabidopsis thaliana.Journal of plant research · 2024Article
- Root rot in medicinal plants: a review of extensive research progress.Frontiers in plant science · 2024Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Plants possess a robust and sophisticated innate immune system against pathogens and must balance growth with rapid pathogen detection and defense. The intracellular receptors with nucleotide-binding leucine-rich repeat (NLR) motifs recognize pathogen-derived effector proteins and thereby trigger the immune response. The expression of genes encoding NLR receptors is precisely controlled in multifaceted ways. The alternative splicing (AS) of introns in response to infection is recurrently observed but poorly understood. Here we report that the potato (Solanum tuberosum) NLR gene RB undergoes AS of its intron, resulting in 2 transcriptional isoforms, which coordinately regulate plant immunity and growth homeostasis. During normal growth, RB predominantly exists as an intron-retained isoform RB_IR, encoding a truncated protein containing only the N-terminus of the NLR. Upon late blight infection, the pathogen induces intron splicing of RB, increasing the abundance of RB_CDS, which encodes a full-length and active R protein. By deploying the RB splicing isoforms fused with a luciferase reporter system, we identified IPI-O1 (also known as Avrblb1), the RB cognate effector, as a facilitator of RB AS. IPI-O1 directly interacts with potato splicing factor StCWC15, resulting in altered localization of StCWC15 from the nucleoplasm to the nucleolus and nuclear speckles. Mutations in IPI-O1 that eliminate StCWC15 binding also disrupt StCWC15 re-localization and RB intron splicing. Thus, our study reveals that StCWC15 serves as a surveillance facilitator that senses the pathogen-secreted effector and regulates the trade-off between RB-mediated plant immunity and growth, expanding our understanding of molecular plant-microbe interactions.
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