Evidence map›Paper›PMID 38941307›Full record

ArticleACS sensors2024

Polymer-Tethered Quenched Fluorescent Probes for Enhanced Imaging of Tumor-Associated Proteases.

Martin Hadzima, Franco F Faucher, Kristýna Blažková, Joshua J Yim, Matteo Guerra, Shiyu Chen, Emily C Woods, Ki Wan Park, Pavel Šácha, Vladimír Šubr and 5 more

Abstract read
In one paragraph

Article in ACS sensors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Martin HadzimaInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, Praha 6 16610, Czech Republic.
Franco F FaucherDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Kristýna BlažkováDepartment of Pathology, School of Medicine, Stanford University, Stanford, California 94305, United States.
Joshua J YimDepartment of Pathology, School of Medicine, Stanford University, Stanford, California 94305, United States.
Matteo GuerraDepartment of Pathology, School of Medicine, Stanford University, Stanford, California 94305, United States.
Shiyu ChenDepartment of Pathology, School of Medicine, Stanford University, Stanford, California 94305, United States.
Emily C WoodsDepartment of Pathology, School of Medicine, Stanford University, Stanford, California 94305, United States.ORCID 0000-0003-3140-8458
Ki Wan ParkDepartment of Pathology, School of Medicine, Stanford University, Stanford, California 94305, United States.
Pavel ŠáchaInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, Praha 6 16610, Czech Republic.
Vladimír ŠubrInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského n. 2, Praha 6 16206, Czech Republic.
Libor KostkaInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského n. 2, Praha 6 16206, Czech Republic.ORCID 0000-0002-7770-1855
Tomáš EtrychInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského n. 2, Praha 6 16206, Czech Republic.ORCID 0000-0001-5908-5182
Pavel MajerInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, Praha 6 16610, Czech Republic.
Jan KonvalinkaInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, Praha 6 16610, Czech Republic.
Matthew BogyoDepartment of Pathology, School of Medicine, Stanford University, Stanford, California 94305, United States.ORCID 0000-0003-3753-4412

Funding

Graduate Training Program in BiotechnologyT32GM141819 · NIGMS · STANFORD UNIVERSITY · PI Eric Andrew Appel, Fan Yang · 2021 to 2026
$1.9M
Dual orthogonal fluorescent protease sensors for image guided surgeryR01EB028628 · NIBIB · STANFORD UNIVERSITY · PI BOGYO, MATTHEW · 2019 to 2023
$1.9M
NIBIB NIH HHS R01 EB028628NIGMS NIH HHS T32 GM141819
6 · The paper itself

Abstract

Fluorescence-based contrast agents enable real-time detection of solid tumors and their neovasculature, making them ideal for use in image-guided surgery. Several agents have entered late-stage clinical trials or secured FDA approval, suggesting they are likely to become the standard of care in cancer surgeries. One of the key parameters to optimize in contrast agents is molecular size, which dictates much of the pharmacokinetic and pharmacodynamic properties of the agent. Here, we describe the development of a class of protease-activated quenched fluorescent probes in which a

Indexed as

Fluorescent DyesNeoplasmsAcrylamidesAnimalsCell Line, TumorHumansMiceOptical ImagingPeptide HydrolasesPolymersAcrylamidesFluorescent DyesN-(2-hydroxypropyl)methacrylamidePeptide HydrolasesPolymerscancerfluorescenceHPMA copolymeriBodyimagingprotease

Identifiers

PMID38941307
PMCPMC11287742

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.