ArticleeLife2024
Neural interactions in the human frontal cortex dissociate reward and punishment learning.
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of neural correlates of working memory, reward, and emotion processing in major depressive disorder using ALE.Psychological medicine · 2026Pooled it
- Charting higher-order models of brain function beyond pairwise interactions.Nature communications · 2026Article
- Belief updating in uncertain environments is differentially sensitive to reward and punishment learning: Evidence from ERP.iScience · 2026Article
- Broadband synergy versus oscillatory redundancy in the visual cortex.Nature communications · 2026Article
- Broadband synergy versus oscillatory redundancy in the visual cortex.bioRxiv : the preprint server for biology · 2025Article
- Reward circuit local field potential modulations precede risk taking.Brain : a journal of neurology · 2025Article
- Evidence of Altered Biobehavioral Threat Processes in Adolescents With Eating Disorders: A Scoping Review.The International journal of eating disorders · 2025Article
- Higher-order and distributed synergistic functional interactions encode information gain in goal-directed learning.Nature communications · 2025Article
- Early Salience Signals Predict Interindividual Asymmetry in Decision Accuracy Across Rewarding and Punishing Contexts.Human brain mapping · 2024Article
- Higher-order connectomics of human brain function reveals local topological signatures of task decoding, individual identification, and behavior.Nature communications · 2024Article
- Neural interactions in the human frontal cortex dissociate reward and punishment learning.eLife · 2024Article
- Human local field potentials in motor and non-motor brain areas encode upcoming movement direction.Communications biology · 2024Article
- Cognitive synaptopathy: synaptic and dendritic spine dysfunction in age-related cognitive disorders.Frontiers in aging neuroscience · 2024Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
How human prefrontal and insular regions interact while maximizing rewards and minimizing punishments is unknown. Capitalizing on human intracranial recordings, we demonstrate that the functional specificity toward reward or punishment learning is better disentangled by interactions compared to local representations. Prefrontal and insular cortices display non-selective neural populations to rewards and punishments. Non-selective responses, however, give rise to context-specific interareal interactions. We identify a reward subsystem with redundant interactions between the orbitofrontal and ventromedial prefrontal cortices, with a driving role of the latter. In addition, we find a punishment subsystem with redundant interactions between the insular and dorsolateral cortices, with a driving role of the insula. Finally, switching between reward and punishment learning is mediated by synergistic interactions between the two subsystems. These results provide a unifying explanation of distributed cortical representations and interactions supporting reward and punishment learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.