Evidence map›Paper›PMID 38941161›Full record

ArticleAmerican journal of respiratory and critical care medicine2024

The Renin-Angiotensin-Aldosterone System Regulates Sarcoidosis Granulomatous Inflammation.

Elliott D Crouser, Mark W Julian, Landon W Locke, Sabahattin Bicer, Jonah R Mitchell, Arindam Singha, Patrick J Kramer, Murugesan V S Rajaram, Subha V Raman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory and critical care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Americas Association of Sarcoidosis and other granulomatous disorders 2024 conference highlights.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025
    Article
  3. Article
  4. The effect of adrenalectomy on bleomycin-induced pulmonary fibrosis in mice.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Elliott D CrouserDivision of Pulmonary, Critical Care, and Sleep Medicine, The Dorothy M. Davis Heart and Lung Research Institute.ORCID 0000-0003-3197-6746
Mark W JulianDivision of Pulmonary, Critical Care, and Sleep Medicine, The Dorothy M. Davis Heart and Lung Research Institute.
Landon W LockeDepartment of Biomedical Engineering.
Sabahattin BicerDivision of Pulmonary, Critical Care, and Sleep Medicine, The Dorothy M. Davis Heart and Lung Research Institute.
Jonah R MitchellDepartment of Biomedical Engineering.
Arindam SinghaDivision of Pulmonary, Critical Care, and Sleep Medicine, The Dorothy M. Davis Heart and Lung Research Institute.
Patrick J KramerDivision of Pulmonary, Critical Care, and Sleep Medicine, The Dorothy M. Davis Heart and Lung Research Institute.
Murugesan V S RajaramDepartment of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, Ohio; and.
Subha V RamanOhio Health, Columbus, Ohio.

Funding

Molecular Characterization of Progressive Pulmonary SarcoidosisR01HL162955 · NHLBI · NATIONAL JEWISH HEALTH · PI Maneesh Bhargava, ELLIOTT D CROUSER · 2023 to 2026
$3.2M
Role of Renin-Angiotensin-Aldosterone System during sarcoidosis granuloma formationR21AI168804 · NIAID · OHIO STATE UNIVERSITY · PI CROUSER, ELLIOTT D · 2023 to 2024
$433k
Redox Regulation of Sarcoidosis Granulomas and FibrosisR21AI180862 · NIAID · OHIO STATE UNIVERSITY · PI CROUSER, ELLIOTT D · 2024 to 2025
$433k
National Heart and Lung Institute RO1HL162955National Institute of Allergy and Infectious Diseases R21AI168804NHLBI NIH HHS R01 HL162955NIAID NIH HHS R21 AI168804NIAID NIH HHS R21 AI180862
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AldosteroneCytochrome P-450 CYP11B2GranulomaRenin-Angiotensin SystemSarcoidosisAngiotensin-Converting Enzyme InhibitorsCaptoprilCytokinesEplerenoneFemaleHumansInflammationLeukocytes, MononuclearLosartanMaleMiddle AgedAldosteroneAngiotensin-Converting Enzyme InhibitorsCaptoprilCytochrome P-450 CYP11B2CytokinesEplerenoneLosartanMineralocorticoid Receptor AntagonistsPeptidyl-Dipeptidase ASpironolactoneACE1angiotensin receptor 1CYP11B2granulomamineralocorticoid receptor

Identifiers

PMID38941161
PMCPMC11351795

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.