Evidence map›Paper›PMID 38941144›Full record

ArticleActa crystallographica. Section D, Structural biology2024

A structural role for tryptophan in proteins, and the ubiquitous Trp C

Michal Szczygiel, Urszula Derewenda, Steve Scheiner, Wladek Minor, Zygmunt S Derewenda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta crystallographica. Section D, Structural biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michal SzczygielDepartment of Molecular Physiology and Biological Physics, University of Virginia, 1340 Jefferson Park Avenue, Charlottesville, VA 22908-0736, USA.
Urszula DerewendaDepartment of Molecular Physiology and Biological Physics, University of Virginia, 1340 Jefferson Park Avenue, Charlottesville, VA 22908-0736, USA.
Steve ScheinerDepartment of Chemistry and Biochemistry, Utah State University, Logan, Utah, USA.
Wladek MinorDepartment of Molecular Physiology and Biological Physics, University of Virginia, 1340 Jefferson Park Avenue, Charlottesville, VA 22908-0736, USA.
Zygmunt S DerewendaDepartment of Molecular Physiology and Biological Physics, University of Virginia, 1340 Jefferson Park Avenue, Charlottesville, VA 22908-0736, USA.

Funding

Molecular Mechanisms of RhoA-mediated Ca2+Sensitization in Vascular Smooth MuscleR01GM086457 · NIGMS · UNIVERSITY OF VIRGINIA · PI DEREWENDA, URSZULA, DEREWENDA, ZYGMUNT S · 2009 to 2017
$5.4M
Reproducible, Unbiased Ligand Identification Assisted by Artificial Intelligence and Development of Ligand Reference LibrariesR01GM132595 · NIGMS · UNIVERSITY OF VIRGINIA · PI MINOR, WLADEK · 2019 to 2022
$2.3M
NIGMS NIH HHS R01 GM086457NIGMS NIH HHS R01 GM132595NIH HHS GM086457NIH HHS GM132595
6 · The paper itself

Abstract

Tryptophan is the most prominent amino acid found in proteins, with multiple functional roles. Its side chain is made up of the hydrophobic indole moiety, with two groups that act as donors in hydrogen bonds: the N

Indexed as

Hydrogen BondingProteinsTryptophanCrystallography, X-RayModels, MolecularProtein ConformationProteinsTryptophanC—H...O bondshydrogen bondsprotein structuretryptophan

Identifiers

PMID38941144
PMCPMC11220837

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.