Evidence map›Paper›PMID 38941044›Full record

ReviewChinese journal of integrative medicine2025

Mechanism of Reactive Oxygen/Nitrogen Species in Liver Ischemia-Reperfusion Injury and Preventive Effect of Chinese Medicine.

Lei Gao, Yun-Jia Li, Jia-Min Zhao, Yu-Xin Liao, Meng-Chen Qin, Jun-Jie Li, Hao Shi, Nai-Kei Wong, Zhi-Ping Lyu, Jian-Gang Shen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Chinese journal of integrative medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lei GaoSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
Yun-Jia LiThe First Affiliated Hospital/the First Clinical Medicine School of Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Jia-Min ZhaoSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
Yu-Xin LiaoSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
Meng-Chen QinSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
Jun-Jie LiSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
Hao ShiSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
Nai-Kei WongState Key Discipline of Infectious Diseases, Shenzhen Third People's Hospital, the Second Affiliated Hospital, Shenzhen University, Shenzhen, 518112, Guangdong Province, China.
Zhi-Ping LyuSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
Jian-Gang ShenSchool of Chinese Medicine, the University of Hong Kong, Hong Kong SAR, China. shenjg@hku.hk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver ischemia-reperfusion injury (LIRI) is a pathological process involving multiple injury factors and cell types, with different stages. Currently, protective drugs targeting a single condition are limited in efficacy, and interventions on immune cells will also be accompanied by a series of side effects. In the current bottleneck research stage, the multi-target and obvious clinical efficacy of Chinese medicine (CM) is expected to become a breakthrough point in the research and development of new drugs. In this review, we summarize the roles of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in various stages of hepatic ischemia-reperfusion and on various types of cells. Combined with the current research progress in reducing ROS/RNS with CM, new therapies and mechanisms for the treatment of hepatic ischemia-reperfusion are discussed.

Indexed as

Drugs, Chinese HerbalLiverMedicine, Chinese TraditionalReactive Nitrogen SpeciesReactive Oxygen SpeciesReperfusion InjuryAnimalsHumansDrugs, Chinese HerbalReactive Nitrogen SpeciesReactive Oxygen SpeciesChinese medicineischemia-reperfusion injurylivernitrogenoxygenreview

Identifiers

PMID38941044

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.