Evidence map›Paper›PMID 38941041›Full record

ArticleHead and neck pathology2024

Intraoral CD30+ T-Cell Lymphoproliferative Disorder with Lymphomatoid Papulosis Type C Features Mimics Lymphoma Histopathologically and Immunohistochemically.

Camila Oliveira Barbeiro, Heitor Albergoni Silveira, Roberto Henrique Barbeiro, Karina Helen Martins, Andreia Bufalino, Fernando Chahud, Jorge Esquiche León

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PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Camila Oliveira BarbeiroOral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School, São Paulo State University (Unesp), Araraquara, São Paulo, Brazil.
Heitor Albergoni SilveiraCentro Universitário Estácio Ribeirão Preto, Ribeirão Preto, SP, Brazil.
Roberto Henrique BarbeiroOral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School, São Paulo State University (Unesp), Araraquara, São Paulo, Brazil.
Karina Helen MartinsOral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School, University of São Paulo (FORP/USP), Ribeirão Preto, SP, 14040-904, Brazil.
Andreia BufalinoOral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School, São Paulo State University (Unesp), Araraquara, São Paulo, Brazil.
Fernando ChahudDepartment of Pathology and Forensic Medicine, Ribeirão Preto Medical School (FMRP/USP), University of São Paulo, Ribeirão Preto, SP, Brazil.
Jorge Esquiche LeónOral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School, University of São Paulo (FORP/USP), Ribeirão Preto, SP, 14040-904, Brazil. jleon@forp.usp.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (304241/2021-0)Fundação de Amparo à Pesquisa do Estado de São Paulo (2016/11419-0; 2022/07479-9 and 2022/12760-9)
6 · The paper itself

Abstract

backgroundPrevious studies have shown that at least a of intraoral eosinophilic ulcer is best classified as a CD30 + T-cell lymphoproliferative disorder (LPD), with histopathology reminiscent of lymphomatoid papulosis (LyP) of the skin. Microscopically, a mixed population of inflammatory cells, often including eosinophils and varying numbers of atypical lymphoid cells, frequently expressing CD30, is typical for LyP, whose clinicopathological spectrum includes type A, B, C, D, E, and LyP with DUSP22/IRF4 rearrangement. To date, about 27 intraoral LyP cases have been reported. Of them, 7 cases were diagnosed as LyP type C, which is frequently confused with anaplastic large cell lymphoma (ALCL) on histopathology.

methodsA 60-year-old male was referred for a one-month history of a tongue ulcer.

resultsMicroscopy showed numerous subepithelial atypical large lymphoid cells, which expressed CD4 (with partial loss of CD3, CD5, and CD7), CD8 (few cells), CD30 (about 50%, in non-diffuse pattern with size variability), TIA-1, and Ki-67 (85%), without staining for CD56, ALK, LMP1, and EBER1/2, concerning for a diagnosis of ALCL. However, after three weeks, the lesion completely healed.

conclusionWe present here a rare case of intraoral CD30+ T-cell LPD that we believe is the oral counterpart of cutaneous LyP type C.

Indexed as

Ki-1 AntigenLymphomatoid PapulosisBiomarkers, TumorDiagnosis, DifferentialHumansImmunohistochemistryLymphoproliferative DisordersMaleMiddle AgedT-LymphocytesBiomarkers, TumorKi-1 AntigenAnaplastic large cell lymphomaDifferential diagnosisLymphomatoid papulosis type CLymphoproliferative disorderOral cavity

Identifiers

PMID38941041
PMCPMC11213839

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