Evidence map›Paper›PMID 38941038›Full record

ArticleStem cell reviews and reports2024

Nicotinamide Riboside Promotes the Proliferation of Endogenous Neural Stem Cells to Repair Spinal Cord Injury.

Jianping Zhang, Jun Shang, Han Ding, Wenxiang Li, Zonghao Li, Zhongze Yuan, Han Zheng, YongFu Lou, Zhijian Wei, Hengxing Zhou and 3 more

Abstract read
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In one paragraph

Article in Stem cell reviews and reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jianping Zhang *Tianjin Key Laboratory of Spine and Spinal Cord, National Spinal Cord Injury International Cooperation Base, Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China.
Jun Shang *Institute of Medical Sciences, The Second Hospital & Orthopedic Research Center of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Han Ding *Tianjin Key Laboratory of Spine and Spinal Cord, National Spinal Cord Injury International Cooperation Base, Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China.
Wenxiang LiDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Zonghao LiDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Zhongze YuanDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Han ZhengDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, China.
YongFu LouInstitute of Medical Sciences, The Second Hospital & Orthopedic Research Center of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Zhijian WeiDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Hengxing ZhouDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Shiqing FengInstitute of Medical Sciences, The Second Hospital & Orthopedic Research Center of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. shiqingfeng@sdu.edu.cn.
Xiaohong KongInstitute of Medical Sciences, The Second Hospital & Orthopedic Research Center of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. kongxh@sdu.edu.cn.
Ning RanInstitute of Medical Sciences, The Second Hospital & Orthopedic Research Center of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. NingRan@sdu.edu.cn.ORCID 0009-0007-9149-5940

Funding

Clinical Research Center of Shandong University 2020SDUCRCA008National Key Research and Development Program of China Stem Cell and Translational Research 2019YFA0112100National Natural Science Foundation of China 82102560National Natural Science Foundation of China 82220108005
6 · The paper itself

Abstract

Activation of endogenous neural stem cells (NSC) is one of the most potential measures for neural repair after spinal cord injury. However, methods for regulating neural stem cell behavior are still limited. Here, we investigated the effects of nicotinamide riboside promoting the proliferation of endogenous neural stem cells to repair spinal cord injury. Nicotinamide riboside promotes the proliferation of endogenous neural stem cells and regulates their differentiation into neurons. In addition, nicotinamide riboside significantly restored lower limb motor dysfunction caused by spinal cord injury. Nicotinamide riboside plays its role in promoting the proliferation of neural stem cells by activating the Wnt signaling pathway through the LGR5 gene. Knockdown of the LGR5 gene by lentivirus eliminates the effect of nicotinamide riboside on the proliferation of endogenous neural stem cells. In addition, administration of Wnt pathway inhibitors also eliminated the proliferative effect of nicotinamide riboside. Collectively, these findings demonstrate that nicotinamide promotes the proliferation of neural stem cells by targeting the LGR5 gene to activate the Wnt pathway, which provides a new way to repair spinal cord injury.

Indexed as

Cell ProliferationNeural Stem CellsNiacinamidePyridinium CompoundsSpinal Cord InjuriesWnt Signaling PathwayAnimalsCell DifferentiationFemaleRatsRats, Sprague-DawleyReceptors, G-Protein-CoupledNiacinamidenicotinamide-beta-ribosidePyridinium CompoundsReceptors, G-Protein-CoupledLGR5 geneNeural stem cellsNeurogenesisNicotinamide ribosideSpinal cord injury

Identifiers

PMID38941038

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.