Evidence map›Paper›PMID 38940871›Full record

ArticleAnalytical and bioanalytical chemistry2024

A new HPLC method with multiple detection systems for impurity analysis and discrimination of natural versus synthetic cannabidiol.

Virginia Brighenti, Matilde Marani, Clarissa Caroli, Laura Bertarini, Alessio Gaggiotti, Federica Pollastro, Caterina Durante, Giuseppe Cannazza, Federica Pellati

Abstract read
In one paragraph

Article in Analytical and bioanalytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Interpol review of forensic drug chemistry, 2022-2025.Forensic science international. Synergy · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Virginia BrighentiDepartment of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, Modena, 41125, Italy.
Matilde MaraniDepartment of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, Modena, 41125, Italy.
Clarissa CaroliDepartment of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, Modena, 41125, Italy.
Laura BertariniDepartment of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, Modena, 41125, Italy.
Alessio GaggiottiFarmech, Piazza Duomo 20, Milan, 20122, Italy.
Federica PollastroDepartment of Pharmaceutical Sciences, University of Eastern Piedmont, Largo Donegani 2, Novara, 28100, Italy.
Caterina DuranteDepartment of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, Modena, 41125, Italy.
Giuseppe CannazzaDepartment of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, Modena, 41125, Italy.
Federica PellatiDepartment of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, Modena, 41125, Italy. federica.pellati@unimore.it.ORCID http://orcid.org/0000-0002-9822-6862

Funding

European Union - Next Generation EU NOrCa - Not Ordinary Cannabis - Exploring the chemItalian Ministry of University and Research (MIUR) PON research project entitled "Cannabis sativa L
6 · The paper itself

Abstract

Cannabidiol (CBD) is the main non-psychoactive phytocannabinoid derived from Cannabis sativa L. It is now an active pharmaceutical ingredient (API), given its usage in treating some types of pediatric epilepsy. For this reason, this compound requires a deep characterization in terms of purity and origin. Previous research work has shown two impurities in CBD samples from hemp inflorescences, namely, cannabidivarin (CBDV) and cannabidibutol (CBDB), while abnormal-cannabidiol (abn-CBD) has been described as the primary by-product that is generated from CBD synthesis. Both natural and synthetic CBD samples exhibit the presence of Δ

Indexed as

CannabidiolDrug ContaminationCannabinoidsCannabisChromatography, High Pressure LiquidLimit of DetectionCannabidiolCannabinoidsCannabidiolChiral analysisHPLCHRMSImpurityOrigin

Identifiers

PMID38940871
PMCPMC11294429

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.