Evidence map›Paper›PMID 38940708›Full record

ArticleSarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG2024

Pulmonary function in patients with ANCA-associated vasculitis.

Johannes Dieterich, Bernhard Hellmich, Juliane Mahrhold, You-Shan Feng, Abdallah El Rai, Felix Nessyt, Ulrich Specks, Jürgen Hetzel, Christian Löffler

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Article in Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Johannes Dieterichmedius Klinik Kirchheim, Department of Internal Medicine, Rheumatology, Pulmonology, Nephrology and Diabetology.
Bernhard Hellmichmedius Klinik Kirchheim, Department of Internal Medicine, Rheumatology, Pulmonology, Nephrology and Diabetology.
Juliane Mahrholdmedius Klinik Kirchheim, Department of Internal Medicine, Rheumatology, Pulmonology, Nephrology and Diabetology.
You-Shan FengInstitute for Clinical Epidemiology and Biometry, University of Tübingen, Tübingen, Germany.
Abdallah El RaiDepartment of Radiology and Nuclear Medicine, medius Kliniken Nürtingen, University of Tübingen, Nürtingen, Germany.
Felix Nessytmedius Klinik Kirchheim, Department of Internal Medicine, Rheumatology, Pulmonology, Nephrology and Diabetology.
Ulrich SpecksDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Jürgen HetzelDepartment of Pneumology, University Hospital of Tübingen, Tübingen, Germany.
Christian Löfflermedius Klinik Kirchheim, Department of Internal Medicine, Rheumatology, Pulmonology, Nephrology and Diabetology.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimAlthough pulmonary manifestations occur frequently in ANCA-associated vasculitis (AAV), empirical evidence of their impact on pulmonary function is scarce. This study analyzed pulmonary function test (PFT) data from a large cohort of patients with AVV. Results were correlated with findings from diagnostic imaging and disease activity.

methodsData from AAV patients with PFTs performed between 2008 and 2018 were extracted retrospectively from the database of a tertiary vasculitis center. Demographic and disease characteristics, imaging data and follow-up results were assessed and compared to PFT results.

resultsThe final analysis encompassed 147 patients. The mean time between first PFT and follow-up was 7.0 ± 11.0 months. In Granulomatosis with Polyangiitis (GPA), forced expiratory vital capacity (FVCex, p<0.001), residual volume (RV, p<0.001) and the diffusion capacity of carbon oxide (TLCO, p=0.003) were significantly reduced compared to the reference value of 100% predicted. There was no significant difference between patients with or without pulmonary manifestations. In Microscopic Polyangiitis (MPA), reductions of FVCex (p<0.001), TLC (p=0.005), and TLCO (p=0.003) were observed. In Eosinophilic Granulomatosis with Polyangiitis (EGPA), total airway resistance (RAWtot, p=0.024) and RV (p=0.009) were significantly elevated and TLCO was reduced (p=0.014). Interstitial lung disease (ILD) is associated with a decline of FVCex (-15.7%, p=0.0028), TLC (-26.5%, p<0.001), RV (-38.9%, p=0.023) and TLCO (-29.1%, p=0.007). Significant differences were neither detected between first PFT and follow-up examination, nor between patients with active versus inactive disease.

conclusionsAAV patients presented with characteristic alterations in PFTs according to their respective pulmonary and/or airway manifestations. These results did not change over time and were independent from vasculitis activity.

Identifiers

PMID38940708
PMCPMC11275547

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