Evidence map›Paper›PMID 38940586›Full record

ArticleJournal of virology2024

Justine Girard, Olivier Le Bihan, Joséphine Lai-Kee-Him, Maria Girleanu, Eric Bernard, Cedric Castellarin, Matthew Chee, Aymeric Neyret, Danièle Spehner, Xavier Holy and 3 more

Abstract read
In one paragraph

Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. The SMARCA4-TMEM47 axis plays an essential role in chikungunya virus RNA replication.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Justine GirardCentre de Biologie Structurale (CBS), Université de Montpellier, CNRS, INSERM, Montpellier, France.
Olivier Le BihanInstitut de Recherche Biomédicale des Armées (IRBA), Ministère des armées, Brétigny-sur-Orge, France.
Joséphine Lai-Kee-HimCentre de Biologie Structurale (CBS), Université de Montpellier, CNRS, INSERM, Montpellier, France.
Maria GirleanuInstitut de Recherche Biomédicale des Armées (IRBA), Ministère des armées, Brétigny-sur-Orge, France.
Eric BernardInstitut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, CNRS, Montpellier, France.
Cedric CastellarinInstitut de Recherche Biomédicale des Armées (IRBA), Ministère des armées, Brétigny-sur-Orge, France.
Matthew CheeCentre de Biologie Structurale (CBS), Université de Montpellier, CNRS, INSERM, Montpellier, France.
Aymeric NeyretInstitut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, CNRS, Montpellier, France.
Danièle SpehnerInstitut de Recherche Biomédicale des Armées (IRBA), Ministère des armées, Brétigny-sur-Orge, France.
Xavier HolyInstitut de Recherche Biomédicale des Armées (IRBA), Ministère des armées, Brétigny-sur-Orge, France.
Anne-Laure FavierInstitut de Recherche Biomédicale des Armées (IRBA), Ministère des armées, Brétigny-sur-Orge, France.
Laurence BriantInstitut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, CNRS, Montpellier, France.ORCID 0000-0002-1995-3501
Patrick BronCentre de Biologie Structurale (CBS), Université de Montpellier, CNRS, INSERM, Montpellier, France.ORCID 0000-0002-3354-9513

Funding

Agence Nationale de la Recherche (ANR) ANR-18-CE11-002Fondation pour la Recherche Médicale (FRM) FRM FDT202106013092French Infrastructure for Integrated Structural Biology (FRISBI) ANR-10-INBS-05
6 · The paper itself

Abstract

Chikungunya virus (CHIKV) is a mosquito-borne pathogen responsible for an acute musculoskeletal disease in humans. Replication of the viral RNA genome occurs in specialized membranous replication organelles (ROs) or spherules, which contain the viral replication complex. Initially generated by RNA synthesis-associated plasma membrane deformation, alphavirus ROs are generally rapidly endocytosed to produce type I cytopathic vacuoles (CPV-I), from which nascent RNAs are extruded for cytoplasmic translation. By contrast, CHIKV ROs are poorly internalized, raising the question of their fate and functionality at the late stage of infection. Here, using

Indexed as

Chikungunya virusRNA, ViralVirus ReplicationAnimalsCell LineCell MembraneChikungunya FeverCryoelectron MicroscopyGenome, ViralHumansOrganellesViral Replication CompartmentsRNA, ViralalphavirusCEMOVISChikungunyacryogenic-electron microscopyelectron tomographynsP1replication organellessub-tomogram averaging

Identifiers

PMID38940586
PMCPMC11265437

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.