Evidence map›Paper›PMID 38940523›Full record

ArticlemSystems2024

Metabolic model guided CRISPRi identifies a central role for phosphoglycerate mutase in

Niaz Bahar Chowdhury, Nick Pokorzynski, Elizabeth A Rucks, Scot P Ouellette, Rey A Carabeo, Rajib Saha

Abstract read
In one paragraph

Article in mSystems, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Niaz Bahar ChowdhuryChemical and Biomolecular Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.ORCID 0009-0005-3833-6380
Nick PokorzynskiDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID 0000-0003-2438-2368
Elizabeth A RucksDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID 0000-0002-0536-7691
Scot P OuelletteDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID 0000-0002-3721-6839
Rey A CarabeoDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID 0000-0002-5708-5493
Rajib SahaChemical and Biomolecular Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.ORCID 0000-0002-2974-0243

Funding

Regulatory Role of Tandem Tryptophan Codons in Chlamydial PersistenceR01AI132406 · NIAID · WASHINGTON STATE UNIVERSITY · PI CARABEO, REY A, OUELLETTE, SCOT P · 2019 to 2023
$2.9M
A Predictive Modeling Framework to Dissect the Dynamic Immunometabolic Responses to Pathogenic infection and the Kinetic Reprogramming of Metabolism in Cancer Cell SystemR35GM143009 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI SAHA, RAJIB · 2021 to 2025
$1.8M
Functional relevance of C. trachomatis trp operon polymorphismR01AI173341 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI REY A CARABEO · 2024 to 2026
$1.8M
National Institute of Health R35 MIRA 5R35GM143009National Science Foundation (NSF) 1943310Nebraska Collaboration Initiative AI132406NIAID NIH HHS R01 AI132406NIAID NIH HHS R01 AI173341NIGMS NIH HHS R35 GM143009
6 · The paper itself

Abstract

Upon nutrient starvation, IMPORTANCE: This study uses a metabolic model to investigate factors that contribute to the persistence of

Indexed as

Chlamydia trachomatisPhosphoglycerate MutaseBacterial ProteinsGene Expression Regulation, BacterialHumansModels, BiologicalBacterial ProteinsPhosphoglycerate MutaseC. trachomatisglobal stress responsemetabolic bottlenecknutrient starvationpersistence

Identifiers

PMID38940523
PMCPMC11323709

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.