Evidence map›Paper›PMID 38940296›Full record

ArticleChemMedChem2024

Elucidating the Unconventional Binding Mode of a DNA-Encoded Library Hit Provides a Blueprint for Sirtuin 6 Inhibitor Development.

Weijie You, Alba L Montoya, Srikanta Dana, Raphael M Franzini, Clemens Steegborn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Weijie YouDepartment of Biochemistry, University of Bayreuth, Universitaetsstr. 30, 95447, Bayreuth, Germany.
Alba L MontoyaDepartment of Medicinal Chemistry, Skaggs College of Pharmacy, University of Utah, 30 S 2000 E, Salt Lake City, 84112, UT, USA.
Srikanta DanaDepartment of Medicinal Chemistry, Skaggs College of Pharmacy, University of Utah, 30 S 2000 E, Salt Lake City, 84112, UT, USA.
Raphael M FranziniDepartment of Medicinal Chemistry, Skaggs College of Pharmacy, University of Utah, 30 S 2000 E, Salt Lake City, 84112, UT, USA.
Clemens SteegbornDepartment of Biochemistry, University of Bayreuth, Universitaetsstr. 30, 95447, Bayreuth, Germany.ORCID https://orcid.org/0000-0002-0913-1467

Funding

Targeting Cardiovascular Disease with SIRT6 ActivatorsR21AG070740 · NIA · UNIVERSITY OF UTAH · PI FRANZINI, RAPHAEL M. · 2021 to 2022
$433k
NIA NIH HHS R21 AG070740University of Utah Synthesis Core Facility
6 · The paper itself

Abstract

Sirtuin 6 (Sirt6), an NAD

Indexed as

DNASirtuinsBinding SitesCrystallography, X-RayDose-Response Relationship, DrugDrug DevelopmentEnzyme InhibitorsGene LibraryHumansModels, MolecularMolecular StructureStructure-Activity RelationshipDNAEnzyme InhibitorsSIRT6 protein, humanSirtuinsAcyl binding pocketCrystal structureDeacylaseDNA-encoded chemical librariesSirt6 inhibition

Identifiers

PMID38940296
PMCPMC11486586

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.