Evidence map›Paper›PMID 38940253›Full record

ArticleThe International journal of eating disorders2024

Shared Genetic Influences Between Loss-of-Control Eating and Body Mass Index in Adolescent Twins.

Camden E Matherne, Baiyu Qi, Soo Hyun Rhee, Michael C Stallings, Robin P Corley, John K Hewitt, Melissa A Munn-Chernoff

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The International journal of eating disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Camden E MatherneDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0003-0659-9141
Baiyu QiDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0003-0768-7055
Soo Hyun RheeDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado, USA.
Michael C StallingsDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado, USA.
Robin P CorleyInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, Colorado, USA.
John K HewittDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado, USA.
Melissa A Munn-ChernoffDepartment of Community, Family, and Addiction Sciences, Texas Tech University, Lubbock, Texas, USA.ORCID 0000-0001-9368-9457

Funding

Colorado Adoption/Twin Study of Lifespan behavioral development & cognitive aging (CATSLife2)R01AG046938 · NIA · UNIVERSITY OF COLORADO · PI REYNOLDS, CHANDRA A, WADSWORTH, SALLY J · 2015 to 2024
$18.5M
Understanding the links between parental and adolescent substance use:complementary natural experiments using the children of twins designR01DA054087 · NIDA · UNIVERSITY OF COLORADO · PI Matthew Charles Keller, SOO H RHEE · 2022 to 2026
$4.9M
DETERMINANTS OF BEHAVIORAL DEVELOPMENT IN CHILDRENR01HD010333 · NICHD · UNIVERSITY OF COLORADO AT BOULDER · PI WADSWORTH, SALLY J · 1985 to 2010
$3.0M
Effects of High Potency Cannabis Products on Mental Health and Psychosocial FunctioningR01DA057894 · NIDA · UNIVERSITY OF COLORADO DENVER · PI Christian J Hopfer · 2023 to 2026
$2.7M
National Institute of Child Health and Human Development HD010333NIA NIH HHS AG046938NIA NIH HHS R01 AG046938NICHD NIH HHS R01 HD010333NIDA NIH HHS DA054087NIDA NIH HHS DA057894NIDA NIH HHS R01 DA054087NIDA NIH HHS R01 DA057894
6 · The paper itself

Abstract

objectivePediatric loss-of-control (LOC) eating is associated with high BMI and predicts binge-eating disorder and obesity onset with age. Research on the etiology of this common comorbidity has not explored the potential for shared genetic risk. This study examined genetic and environmental influences on LOC eating and its shared influence with BMI.

methodParticipants were 499 monozygotic and 398 same-sex dizygotic twins (age = 17.38 years ± 0.67, BMIz = 0.03 ± 1.03, 54% female) from the Colorado Center for Antisocial Drug Dependence Study. LOC eating was assessed dichotomously. Self-reported height and weight were converted to BMIz. Univariate and bivariate twin models estimated genetic and environmental influences on LOC eating and BMIz.

resultsMore girls (21%) than boys (9%, p < 0.001) reported LOC eating. The phenotypic correlation with BMIz was 0.03 in girls and 0.18 in boys. Due to the nonsignificant phenotypic correlation in girls, bivariate twin models were fit in boys only. Across all models, the best-fitting model included genetic and unique environmental effects. Genetic factors accounted for 0.51 (95% CI: 0.23, 0.73) of the variance of LOC eating in girls and 0.54 (0.18, 0.90) in boys. The genetic correlation between LOC eating and BMIz in boys was 0.45 (0.15, 0.75). DISCUSSION: Findings indicate moderate heritability of LOC eating in adolescence, while emphasizing the role of unique environmental factors. In boys, LOC eating and BMIz share a proportion of their genetic influences.

Indexed as

Body Mass IndexTwins, DizygoticAdolescentFeeding and Eating DisordersFeeding BehaviorFemaleHumansMaleTwins, Monozygoticbody mass index z‐scoreheritabilityloss‐of‐control eatingtwins

Identifiers

PMID38940253
PMCPMC11524777

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.