Evidence map›Paper›PMID 38940230›Full record

ArticleClinical transplantation2024

A Tailored Virtual Program for Alcohol Use Disorder Treatment Among Liver Transplant Candidates and Recipients Is Feasible and Associated With Lower Post-Transplant Relapse.

Arpita Goswami, Ethan Weinberg, Lynda Coraluzzi, Therese Bittermann, Jonathan Nahas, Senayish Addis, Robert Weinrieb, Marina Serper

Erratum issuedAbstract read
In one paragraph

Article in Clinical transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Observational
  4. Balancing abstinence and harm reduction across the continuum of care for liver transplantation in alcohol-associated liver disease.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2025
    Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Arpita GoswamiDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Ethan WeinbergDivision of Gastroenterology and Hepatology, School of Medicine, University of Pennsylvania Perelman, Philadelphia, Pennsylvania, USA.
Lynda CoraluzziPenn Presbyterian Medical Center, Philadelphia, Pennsylvania, USA.
Therese BittermannDivision of Gastroenterology and Hepatology, School of Medicine, University of Pennsylvania Perelman, Philadelphia, Pennsylvania, USA.
Jonathan NahasDivision of Gastroenterology and Hepatology, School of Medicine, University of Pennsylvania Perelman, Philadelphia, Pennsylvania, USA.
Senayish AddisPenn Transplant Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Robert WeinriebDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Marina SerperDivision of Gastroenterology and Hepatology, School of Medicine, University of Pennsylvania Perelman, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-4899-2160

Funding

2/4-American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)R01AA030963 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI Marina Serper · 2023 to 2026
$1.6M
NIAAA NIH HHS R01 AA030963
6 · The paper itself

Abstract

backgroundAlcohol-associated liver disease (ALD) is a leading indication for liver transplant (LT) in the United States. Rates of early liver transplant (ELT) with less than 6 months of sobriety have increased substantially. Patients who receive ELT commonly have alcohol-associated hepatitis (AH) and are often too ill to complete an intensive outpatient program (IOP) for alcohol use disorder (AUD) prior to LT. ELT recipients feel alienated from traditional IOPs.

methodsWe implemented Total Recovery-LT, a tailored virtual outpatient IOP specific for patients under evaluation or waitlisted for LT who were too ill to attend community-based alcohol treatment programs. The 12-week program consisted of weekly group and individual counseling delivered by a master's level Certified Addiction Counselor trained in the basics of LT.  Treatment consisted of 12-Step Facilitation, Motivational Interviewing, and Cognitive Behavioral Therapy. We report on program design, implementation, feasibility and early outcomes.

resultsFrom March 2021 to September 2022, 42 patients (36% female, 23 in LT evaluation, 19 post-transplant) enrolled across five cohorts with 76% (32/42) completing the program. Alcohol relapse was more common among noncompleters versus those who completed the program (8/10, 80% vs. 7/32, 22%, p = 0.002). History of trauma or post-traumatic stress symptoms were associated with lower likelihood of completion. Patients' desire for continued engagement after completion led to the creation of a monthly alumni group.

conclusionsOur integrated IOP model for patients with high-risk AUD in LT evaluation or post-transplant is well-received by patients and could be considered a model for LT programs.

Indexed as

AlcoholismFeasibility StudiesLiver TransplantationRecurrenceAdultFemaleFollow-Up StudiesHumansLiver Diseases, AlcoholicMaleMiddle AgedPostoperative ComplicationsPrognosisTelemedicinealcohol‐associated hepatitisintegrated careintensive outpatient programtelehealth

Identifiers

PMID38940230
PMCPMC11273277

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.