Evidence map›Paper›PMID 38940228›Full record

ArticleThe International journal of eating disorders2024

Medical Comorbidities, Nutritional Markers, and Cardiovascular Risk Markers in Youth With ARFID.

Helen Burton-Murray, Aluma Chovel Sella, Julia E Gydus, Micaela Atkins, Lilian P Palmer, Megan C Kuhnle, Kendra R Becker, Lauren E Breithaupt, Kathryn S Brigham, Anna Aulinas and 6 more

Abstract read
In one paragraph

Article in The International journal of eating disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Prevalence of Avoidant/Restrictive Food Intake Disorder (ARFID) in children with and without food allergy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Article
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  4. Article
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  6. Review
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Helen Burton-MurrayHarvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-2059-3256
Aluma Chovel SellaThe Jesse Z. and Sara Lea Shafer Institute of Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
Julia E GydusNeuroendocrine Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Micaela AtkinsHarvard Medical School, Boston, Massachusetts, USA.
Lilian P PalmerEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA.
Megan C KuhnleNeuroendocrine Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Kendra R BeckerHarvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-8946-9977
Lauren E BreithauptHarvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-2439-6519
Kathryn S BrighamHarvard Medical School, Boston, Massachusetts, USA.
Anna AulinasDepartment of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau, IR-SANTPAU, Barcelona, Spain.ORCID 0000-0002-1205-7114
Kyle StallerHarvard Medical School, Boston, Massachusetts, USA.
Kamryn T EddyHarvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-1586-0930
Madhusmita MisraHarvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-9405-2981
Nadia MicaliGreat Ormond Street Institute of Child Health, University College London, London, UK.
Jennifer J ThomasHarvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-2601-581X
Elizabeth A LawsonHarvard Medical School, Boston, Massachusetts, USA.

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
TRAINING PROGRAM IN ENDOCRINOLOGY AND DIABETEST32DK007028 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Karen K Miller · 1986 to 2026
$18.5M
Homeostatic and Hedonic Food Motivation Underlying Eating Disorder TrajectoriesR01MH103402 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI EDDY, KAMRYN T, LAWSON, ELIZABETH AUSTEN · 2014 to 2018
$3.7M
Neurobiological and Behavioral Risk Mechanisms of Youth Avoidant/Restrictive Eating TrajectoriesR01MH108595 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LAWSON, ELIZABETH AUSTEN, MICALI, NADIA · 2016 to 2020
$3.4M
Translational Neuroscience Training for CliniciansT32MH112485 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BUCKNER, RANDY L, ROFFMAN, JOSHUA LAWRENCE · 2018 to 2022
$1.7M
A Biobehavioral Approach to Understand Problematic Avoidant/Restrictive Eating in Adults with Functional DyspepsiaK23DK131334 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BURTON MURRAY, HELEN · 2021 to 2025
$1.1M
The Role of Negative Affect in the Cognitive-Behavioral Model of Avoidant/Restrictive Food Intake Disorder: An Integrated Analysis of Neural Circuitry, Hormones, and Momentary Negative EmotionsK23MH125143 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BECKER, KENDRA R · 2021 to 2025
$1.1M
The Role of Fiber in the Etiopathogenesis of Fecal IncontinenceK23DK120945 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI STALLER, KYLE · 2020 to 2024
$1.0M
Neurobiology of avoidant/restrictive eating in youthK24MH120568 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LAWSON, ELIZABETH AUSTEN · 2019 to 2023
$961k
Mentorship in Biobehavioral Mechanisms of Avoidant/Restrictive Food Intake DisorderK24MH135189 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI JENNIFER JOANNE THOMAS · 2023 to 2026
$747k
NCATS NIH HHS 1UL1TR002541-01NCATS NIH HHS UL1 TR002541NIDDK NIH HHS K23 DK120945NIDDK NIH HHS K23DK120945NIDDK NIH HHS K23 DK131334NIDDK NIH HHS K23DK131334NIDDK NIH HHS P30 DK040561NIDDK NIH HHS T32 DK007028NIMH NIH HHS K23 MH125143NIMH NIH HHS K23MH125143NIMH NIH HHS K24 MH120568NIMH NIH HHS K24MH120568NIMH NIH HHS K24 MH135189NIMH NIH HHS K24MH135189NIMH NIH HHS R01 MH103402NIMH NIH HHS R01MH103402NIMH NIH HHS R01 MH108595NIMH NIH HHS R01MH108595NIMH NIH HHS T32DK007028NIMH NIH HHS T32 MH112485NIMH NIH HHS T32MH112485
6 · The paper itself

Abstract

objectiveAvoidant/restrictive food intake disorder (ARFID) is common among populations with nutrition-related medical conditions. Less is known about the medical comorbidity/complication frequencies in youth with ARFID. We evaluated the medical comorbidities and metabolic/nutritional markers among female and male youth with full/subthreshold ARFID across the weight spectrum compared with healthy controls (HC).

methodIn youth with full/subthreshold ARFID (n = 100; 49% female) and HC (n = 58; 78% female), we assessed self-reported medical comorbidities via clinician interview and explored abnormalities in metabolic (lipid panel and high-sensitive C-reactive protein [hs-CRP]) and nutritional (25[OH] vitamin D, vitamin B12, and folate) markers.

resultsYouth with ARFID, compared with HC, were over 10 times as likely to have self-reported gastrointestinal conditions (37% vs. 3%; OR = 21.2; 95% CI = 6.2-112.1) and over two times as likely to have self-reported immune-mediated conditions (42% vs. 24%; OR = 2.3; 95% CI = 1.1-4.9). ARFID, compared with HC, had a four to five times higher frequency of elevated triglycerides (28% vs. 12%; OR = 4.0; 95% CI = 1.7-10.5) and hs-CRP (17% vs. 4%; OR = 5.0; 95% CI = 1.4-27.0) levels. DISCUSSION: Self-reported gastrointestinal and certain immune comorbidities were common in ARFID, suggestive of possible bidirectional risk/maintenance factors. Elevated cardiovascular risk markers in ARFID may be a consequence of limited dietary variety marked by high carbohydrate and sugar intake.

Indexed as

BiomarkersCardiovascular DiseasesComorbidityAdolescentAvoidant Restrictive Food Intake DisorderChildC-Reactive ProteinFemaleHeart Disease Risk FactorsHumansMaleBiomarkersC-Reactive Proteinallergy and immunologyavoidant/restrictive food intake disorderfeeding and eating disordersfood allergiesgastrointestinal diseasehigh‐sensitive C‐reactive proteinlipid panelmetabolic diseasesnutritional insufficiencytriglycerides

Identifiers

PMID38940228
PMCPMC11687417

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.