ReviewAnimal models and experimental medicine2024
Role of short-chain fatty acids in host physiology.
Review in Animal models and experimental medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed.
- Changing Gastrointestinal Transit Time Alters Microbiome Composition and Bile Acid Metabolism: A Cross-Over Study in Healthy Volunteers.Neurogastroenterology and motility · 2025Trial
- Gut microbiome and metabolic health: mechanisms and precision interventions.Gut microbes · 2026Review
- Multi-omics insights into growth impairment mechanisms in children with persistent diarrhea.Microbiology spectrum · 2026Article
- Elucidating the Multifunctional Roles of Olive Oil By-Products: Phenolic Profiles, Antioxidant Capacity, Probiotic Growth-Promoting and Antimicrobial Activity.Foods (Basel, Switzerland) · 2026Article
- Potential Roles of Escherichia coli in IgA Nephropathy: Evidence, Mechanistic Hypotheses and Microbiota-Targeted Strategies.Microbial biotechnology · 2026Review
- Investigation of Oral Toxicity Mechanisms of Low-Molecular-Weight Polycyclic Aromatic Hydrocarbons and Probiotic Interventions Under the Framework of the "Gut-Lung Axis".Foods (Basel, Switzerland) · 2026Review
- Age-dependent dynamics of cecal caproic acid in free-range Lueyang black-boned chickens and its effects on primary myoblasts.Poultry science · 2026Article
- Research Progress on Mechanisms of Milk-Derived Functional Components in Regulating Bone Health and the Gut-Bone Axis.Nutrients · 2026Review
- Dietary Fiber-Associated Differences in Gut Microbial Community Composition and Predicted Short-Chain Fatty Acid-Related Functional Potential: An In Silico Re-Analysis of 16S rRNA Data.International journal of molecular sciences · 2026Article
- Dietary Supplementation With Oil and Leucine Enhance the Gut Microbiota and Barrier of Offspring During Late Gestation and Lactation of Sows.Journal of animal physiology and animal nutrition · 2026Article
- ABCG2 transporter: Structural and functional associations with gout (Review).International journal of molecular medicine · 2026Review
- Short-Chain Fatty Acids at the Crossroads of Microbiota, Immunometabolism, and Inflammation.Biomedicines · 2026Review
- Review
- Review
- NontoxigenicMicroorganisms · 2026Review
- Deficiency of Natural Plant-Derived Gut Metabolites Is a Potential Cause of Skeletal Deformities in Captive-Bred Green Peafowl (Animals : an open access journal from MDPI · 2026Article
- Gut Microbiota in Metabolic Syndrome: Differences in Microbial Signatures and Clinical Profiles.Medicina (Kaunas, Lithuania) · 2026Review
- Natural Products as Nutritional Supplements in Human Disease Prevention and Management: From Molecular Mechanisms to Clinical Translation.Nutrients · 2026Review
- Bidirectional regulation of gut microbiota and young ruminant host: implications for intestinal development and mucosal immunity.Journal of animal science and biotechnology · 2026Review
- Gut Microbiome-Hormone Interactions and Precision Fermentation in the Prevention of Early Cardiovascular Risk in Adolescents.International journal of molecular sciences · 2026Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Short-chain fatty acids (SCFAs) are major metabolites produced by the gut microbiota through the fermentation of dietary fiber, and they have garnered significant attention due to their close association with host health. As important mediators between the gut microbiota and the host, SCFAs serve as energy substrates for intestinal epithelial cells and maintain homeostasis in host immune and energy metabolism by influencing host epigenetics, activating G protein-coupled receptors, and inhibiting pathogenic microbial infections. This review provides a comprehensive summary of SCFAs synthesis and metabolism and offering an overview of the latest research progress on their roles in protecting gut health, enhancing energy metabolism, mitigating diseases such as cancer, obesity, and diabetes, modulating the gut-brain axis and gut-lung axis, and promoting bone health.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.