ArticleJournal of orthopaedics and sports medicine2024
Chronic Adaptation of Achilles Tendon Tissues upon Injury to Rotator Cuff Tendon in Hyperlipidemic Swine.
Article in Journal of orthopaedics and sports medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Characterization of cutaneous wound healing in swine.JID innovations : skin science from molecules to population health · 2026Article
- Resolvin E1 as a Potential Biomarker of Tendon Retraction Severity in Rotator Cuff Tears.Journal of clinical medicine · 2025Article
- Transcriptional and post-translational mechanisms of ECM remodeling in rotator cuff tendons under hyperlipidemic conditions.Life sciences · 2025Article
- 14-3-3ζ: an optimal housekeeping protein for western blot analysis in swine rotator cuff tendon studies.Molecular and cellular biochemistry · 2025Article
- Research Progress on the Preparation and Application of Decellularized Tendons.Current issues in molecular biology · 2025Review
- Modulation of EGR1 Expression by Hyperglycemia in Swine Rotator Cuff Tendons.Journal of orthopaedics and sports medicine · 2025Article
- Calcified vs. Non-Calcified Tendinopathy of the Rotator Cuff: Clinical Presentations, Prognostic Implications, and Emerging Therapeutic Strategies.Journal of orthopaedics and sports medicine · 2025Article
- Outcomes of Rotator Cuff Repair: Open vs. Arthroscopic Approaches in Patients with Diabetes or Hyperlipidemia.Journal of orthopaedics and sports medicine · 2025Article
- Effect of Metabolic Syndrome in the incidence of Rotator Cuff Injury and Recovery following Surgical Repair.Journal of surgery and research · 2025Article
- Biologically Enhanced Patch in the Healing and Mechanical Stability of Rotator Cuff Tears.Journal of biotechnology and biomedicine · 2024Article
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Authors and funding
2 authors.
Funding
Abstract
The biomechanical properties of the tendon are affected due to the changes in composition of the tendon extracellular matrix (ECM). Age, overuse, trauma and metabolic disorders are a few associated conditions that contribute to tendon abnormalities. Hyperlipidemia is one of the leading factors that contribute to the compromised biomechanical. Injury was made on infraspinatus tendon of hyperlipidemic swines. After 8 weeks (i) infraspinatus tendon from the injury site, (ii) infraspinatus tendon from the contralateral side and (iii) Achilles tendon, were collected and analyzed for ECM components that form the major part in biomechanical properties. Immunostaining of infraspinatus tendon on the injury site had higher staining collagen type-1 (COL1A1), biglycan, prolyl 4-hydroxylase and mohawk but lower staining for decorin than the control group. The Achilles tendon of the swines that had injury on infraspinatus tendon showed a chronic adaptation towards load which was evident from a more organized ECM with increased decorin, mohawk and decreased biglycan, scleraxis. The mechanism behind the collagen turnover and chronic adaptation to load need to be studied in detail with the biomechanical properties.
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