ArticleJACC. Advances2024
Admission Total Leukocyte Count as a Predictor of Mortality in Cardiac Intensive Care Unit Patients.
Article in JACC. Advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Prediction of in-hospital cardiac arrest on general wards using calibrated machine learning.BMJ health & care informatics · 2026Article
- Validation of SOFA-2 score in sepsis and exploration of its extension with additional immune markers.Journal of intensive medicine · 2026Article
- In-hospital mortality predictors of heart failure patients 80 years and older: An observational retrospective single-center experience.Medicine · 2026Observational
- Association Between Nursing Diagnoses and Mortality in Patients with Cardiac Disease: A Retrospective Cohort Study.Clinics and practice · 2026Article
- Knockoff-ML: a knockoff machine learning framework for controlled variable selection and risk stratification in electronic health record data.NPJ digital medicine · 2025Article
- Association of white blood cell count with one-year mortality after cardiac arrest.Resuscitation plus · 2024Article
- Seeking a Treatable Cause of Out-of-Hospital Cardiac Arrest during and after Resuscitation.Journal of clinical medicine · 2024Review
- More Alike Than Not? Predicting Mortality in the Cardiac and Medical Intensive Care Units.JACC. Advances · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Inflammation is a sequela of cardiovascular critical illness and a risk factor for mortality. Objectives: This study aimed to evaluate the association between white blood cell count (WBC) and mortality in a broad population of patients admitted to the cardiac intensive care unit (CICU). Methods: This retrospective cohort study included patients admitted to the Mayo Clinic CICU between 2007 and 2018. We analyzed WBC as a continuous variable and then categorized WBC as low (<4.0 × 10 Results: We included 11,699 patients with a median age of 69.3 years (37.6% females). Median WBC was 9.6 (IQR: 7.4-12.7). Mortality was higher in the low (10.5%), high (12.0%), and very high (33.3%) WBC groups relative to the normal WBC group (5.3%). A rising WBC was incrementally associated with higher in-hospital mortality after adjustment (AICc adjusted OR: 1.03 [95% CI: 1.02-1.04] per 1 × 10 Conclusions: Leukocytosis is associated with an increased mortality risk in a diverse cohort of CICU patients. This readily available marker of systemic inflammation may be useful for risk stratification within the increasingly complex CICU patient population.
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