Evidence map›Paper›PMID 38939698›Full record

ReviewJACC. Advances2022

Machine Learning Approaches for Phenotyping in Cardiogenic Shock and Critical Illness: Part 2 of 2.

Jacob C Jentzer, Corbin Rayfield, Sabri Soussi, David D Berg, Jason N Kennedy, Shashank S Sinha, David A Baran, Emily Brant, Alexandre Mebazaa, Filio Billia and 3 more

Abstract readReview
In one paragraph

Review in JACC. Advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Profiling of Cardiogenic Shock: Incorporating Machine Learning Into Bedside Management.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Observational
  18. Article
  19. Article
  20. Research Priorities in Critical Care Cardiology: JACC Expert Panel.Journal of the American College of Cardiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jacob C JentzerDepartment of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA.
Corbin RayfieldDepartment of Cardiovascular Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
Sabri SoussiDepartment of Anesthesiology and Critical Care, Lariboisière - Saint-Louis Hospitals, DMU Parabol, AP-HP Nord, Inserm UMR-S 942, Cardiovascular Markers in Stress Conditions (MASCOT), University of Paris, Paris, France.
David D BergTIMI Study Group, Department of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Jason N KennedyDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Shashank S SinhaINOVA Heart and Vascular Institute, Inova Fairfax Medical Campus, Falls Church, Virginia, USA.
David A BaranCleveland Clinic Heart Vascular and Thoracic Institute, Weston, Florida, USA.
Emily BrantDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Alexandre MebazaaDepartment of Anesthesiology and Critical Care, Lariboisière - Saint-Louis Hospitals, DMU Parabol, AP-HP Nord, Inserm UMR-S 942, Cardiovascular Markers in Stress Conditions (MASCOT), University of Paris, Paris, France.
Filio BilliaPeter Munk Cardiac Center and Ted Roger's Center for Heart Research, Toronto, Ontario, Canada.
Navin K KapurThe Cardiovascular Center, Tufts Medical Center, Boston, Massachusetts, USA.
Timothy D HenryThe Carl and Edyth Lindner Center for Research and Education at the Christ Hospital Health Network, Cincinnati, Ohio, USA.
Patrick R LawlerPeter Munk Cardiac Center and Ted Roger's Center for Heart Research, Toronto, Ontario, Canada.

Funding

Sepsis subtypes: biology, treatment, and bedside applicationR35GM119519 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Christopher W. Seymour · 2016 to 2026
$4.9M
REMISE study: REMnant biospecimen Investigation in SEpsisR21GM144851 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SEYMOUR, CHRISTOPHER WARREN · 2022 to 2023
$438k
NIGMS NIH HHS R21 GM144851NIGMS NIH HHS R35 GM119519
6 · The paper itself

Abstract

Progress in improving cardiogenic shock (CS) outcomes may have been limited by failure to embrace the heterogeneity of pathophysiologic processes driving the underlying syndrome. To better understand the variability inherent to CS populations, recent algorithms for describing underlying CS disease subphenotypes have been described and validated. These strategies hope to identify specific patient subgroups with more favorable responses to standard therapies, as well as those who require novel treatment approaches. This paper is part 2 of a 2-part state-of-the-art review. In this second article, we present machine learning-based statistical approaches to identifying subphenotypes and discuss their strengths and limitations, as well as evidence from other critical illness syndromes and emerging applications in CS. We then discuss how staging and stratification may be considered in CS clinical trials and finally consider future directions for this emerging area of research.

Indexed as

cardiac intensive care unitcardiogenic shockmortalityphenotypesshock

Identifiers

PMID38939698
PMCPMC11198618

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.